CD2AP and NPHS1

Number of citations of the paper that reports this interaction (PMID 10997929)
21

Data Source:
HPRD (in vivo)

		CD2AP	NPHS1
Gene Name		CD2-associated protein	nephrosis 1, congenital, Finnish type (nephrin)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Plasma Membrane Cell-cell Junction Actin Cytoskeleton Filamentous Actin Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Slit Diaphragm Cell Projection Protein Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding	Protein Binding Myosin Binding Protein Domain Specific Binding Spectrin Binding Alpha-actinin Binding
	Biological Process	Protein Complex Assembly Substrate-dependent Cell Migration, Cell Extension Mitotic Nuclear Division Signal Transduction Negative Regulation Of Transforming Growth Factor Beta1 Production Cell Division Positive Regulation Of Protein Localization To Nucleus Regulation Of Actin Cytoskeleton Reorganization	Cell Adhesion JNK Cascade Skeletal Muscle Tissue Development Myoblast Fusion Excretion Positive Regulation Of Actin Filament Polymerization Glomerular Basement Membrane Development Regulation Of Excretion Glomerular Visceral Epithelial Cell Development
Pathways		Nephrin interactions
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 21460841)
Protein-Protein Interactions		30 interactors: BCAR1 CAPZA1 CBL CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A SH3GL2 SOS1 SOS2 SRC UBC WTIP YES1	11 interactors: CASK CD2AP FYN IQGAP1 KIRREL LYN NCK1 NCK2 NPHS2 SRC YES1
Entrez ID		23607	4868
HPRD ID		05026	04094
Ensembl ID		ENSG00000198087	ENSG00000161270
Uniprot IDs		Q9Y5K6	O60500
PDB IDs		2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Regulation Of Cellular Component Organization Cell Communication Signal Transduction Leukocyte Migration Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of ERBB Signaling Pathway Locomotion Cellular Response To Hormone Stimulus Cellular Response To Organic Substance Blood Coagulation Hemostasis Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Migration Cellular Response To Peptide Hormone Stimulus Regulation Of Immune Response Cellular Response To Peptide Cell Motility Response To Organic Substance Immune Response Regulation Of Immune System Process Regulation Of Body Fluid Levels Positive Regulation Of Organelle Organization Regulation Of Cellular Process Cellular Response To Stimulus Wound Healing Chemotaxis T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stimulus	Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Ephrin Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Adhesion Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Axon Guidance Regulation Of Lymphocyte Activation Neuron Projection Development Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cell Activation Signal Complex Assembly Cell Motility Enzyme Linked Receptor Protein Signaling Pathway T Cell Costimulation Neuron Development Axonogenesis Phagocytosis Axon Development Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Chemotaxis Neuron Differentiation Cell Development Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cell Morphogenesis Involved In Differentiation Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Complex Assembly Movement Of Cell Or Subcellular Component Regulation Of Cell Proliferation
Tagcloud ?		abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	1beta actin actinin actn4 blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Difference) ?		abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	1beta actin actinin actn4 blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Intersection) ?