CD2AP and NR4A1

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid)

		CD2AP	NR4A1
Description		CD2 associated protein	nuclear receptor subfamily 4 group A member 1
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GO Annotations	Cellular Component	Fibrillar Center Ruffle Podosome Nuclear Envelope Lumen Cytoplasm Late Endosome Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Actin Cytoskeleton Axon Dendrite Growth Cone Cell Leading Edge Neuromuscular Junction Filamentous Actin Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Slit Diaphragm Cell Projection Neuron Projection Extracellular Exosome Anchoring Junction Cell Periphery	Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Nuclear Speck Nuclear Membrane
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding Clathrin Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Lipopolysaccharide Binding DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Immunological Synapse Formation Kidney Development Liver Development Endothelium Development Lipid Metabolic Process Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Inflammatory Response Response To Oxidative Stress Actin Filament Organization Signal Transduction Cell Population Proliferation Male Gonad Development Protein Secretion Response To Wounding Response To Virus Gene Expression Protein Transport Cell Migration Actin Filament Polymerization Cell Differentiation Protein Catabolic Process Neuron Projection Development Rab Protein Signal Transduction Glomerulus Development Response To Insulin Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Actin Cytoskeleton Organization Maintenance Of Blood-brain Barrier Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Cell-cell Adhesion Mediated By Cadherin Cell-cell Junction Organization D-glucose Import Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Synaptic Plasticity Lymph Node Development Collateral Sprouting Positive Regulation Of Protein Secretion Synapse Organization T Cell Receptor Signaling Pathway Negative Regulation Of Small GTPase Mediated Signal Transduction Protein Heterooligomerization Cell Division Stress-activated MAPK Cascade Localization Of Cell Adipose Tissue Development Membrane Organization Protein-containing Complex Assembly ERK1 And ERK2 Cascade Response To Transforming Growth Factor Beta Podocyte Differentiation Renal Albumin Absorption Positive Regulation Of Protein Localization To Nucleus Response To Glial Cell Derived Neurotrophic Factor	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Inflammatory Response Signal Transduction Intracellular Receptor Signaling Pathway Detection Of Lipopolysaccharide Endothelial Cell Chemotaxis Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Macrophage Activation Positive Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Fat Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Non-canonical Inflammasome Complex Assembly
Pathways		Nephrin family interactions	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Family history of Alzheimer's disease ( 30617256) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Plasma homocysteine levels ( 26519441) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		34 interacting genes: ARAP3 BCAR1 CAPZA1 CBL CBLB CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A RIN3 SH3GL2 SOS1 SOS2 SRC UBC UBE2I WTIP YES1	86 interacting genes: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATM ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NDRG1 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRA RXRG SERPINA4 SERPING1 SOCS4 STAT3 SUGT1 TCF4 TP53 TRAF2 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579
Entrez ID		23607	3164
HPRD ID		05026	00744
Ensembl ID		ENSG00000198087	ENSG00000123358
Uniprot IDs		Q9Y5K6	F5GXF0 P22736 Q6ZMM6
PDB IDs		2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23 4WCI 4X1V 7DS6 7DS8	2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG 6KZ5 6LC1 8WUY 8Y7L
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol SH3 Domain Binding Cellular Response To Platelet-derived Growth Factor Stimulus Immune Effector Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Platelet-derived Growth Factor Cell-cell Junction Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Immune System Process Regulation Of ERBB Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Insulin Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Actin Filament Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Focal Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Natural Killer Cell Mediated Immunity T Cell Costimulation Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization Response To Growth Factor Membrane Raft Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Transport Cytoplasm Actin Cytoskeleton Organization Leukocyte Migration	Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process TOR Signaling Positive Regulation Of RNA Metabolic Process TORC1 Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Response To Lipid Peroxisome Proliferator Activated Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Binding Ubiquitin Protein Ligase Binding Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Death Positive Regulation Of Biosynthetic Process Protein-containing Complex Cellular Response To Stress Positive Regulation Of Macromolecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleoplasm Intrinsic Apoptotic Signaling Pathway Response To Nutrient Levels Identical Protein Binding MRNA Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Stability Response To Decreased Oxygen Levels Negative Regulation Of RNA Metabolic Process Response To Hormone Negative Regulation Of Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Developmental Process Response To Oxygen Levels MRNA Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Primary Metabolic Process
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