CD2AP and WTIP

Number of citations: 0 (PubMedID 14736876)
Data Source: HPRD (in vivo)

		CD2AP	WTIP
Name		CD2 associated protein	WT1 interacting protein
Structure			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Ruffle Podosome Nuclear Envelope Lumen Cytoplasm Late Endosome Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Actin Cytoskeleton Axon Dendrite Growth Cone Cell Leading Edge Neuromuscular Junction Filamentous Actin Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Slit Diaphragm Cell Projection Neuron Projection Extracellular Exosome Anchoring Junction Cell Periphery	P-body Nucleus Transcription Regulator Complex Cytoplasm Adherens Junction Anchoring Junction
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding Clathrin Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Immunological Synapse Formation Kidney Development Liver Development Endothelium Development Lipid Metabolic Process Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Inflammatory Response Response To Oxidative Stress Actin Filament Organization Signal Transduction Cell Population Proliferation Male Gonad Development Protein Secretion Response To Wounding Response To Virus Gene Expression Protein Transport Cell Migration Actin Filament Polymerization Cell Differentiation Protein Catabolic Process Neuron Projection Development Rab Protein Signal Transduction Glomerulus Development Response To Insulin Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Actin Cytoskeleton Organization Maintenance Of Blood-brain Barrier Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Cell-cell Adhesion Mediated By Cadherin Cell-cell Junction Organization D-glucose Import Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Synaptic Plasticity Lymph Node Development Collateral Sprouting Positive Regulation Of Protein Secretion Synapse Organization T Cell Receptor Signaling Pathway Negative Regulation Of Small GTPase Mediated Signal Transduction Protein Heterooligomerization Cell Division Stress-activated MAPK Cascade Localization Of Cell Adipose Tissue Development Membrane Organization Protein-containing Complex Assembly ERK1 And ERK2 Cascade Response To Transforming Growth Factor Beta Podocyte Differentiation Renal Albumin Absorption Positive Regulation Of Protein Localization To Nucleus Response To Glial Cell Derived Neurotrophic Factor	Response To Hypoxia Regulation Of DNA-templated Transcription Cytoskeleton Organization Regulation Of Cell Morphogenesis Cell Projection Organization Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Hippo Signaling Negative Regulation Of DNA-templated Transcription
Pathways		Nephrin family interactions	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis	None
GWAS		Alzheimer's disease ( 31473137 ) Alzheimer's disease (late onset) ( 21460841 24162737 30617256 ) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Family history of Alzheimer's disease ( 30617256 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) High light scatter reticulocyte count ( 27863252 ) High light scatter reticulocyte percentage of red cells ( 27863252 ) Hip circumference adjusted for BMI ( 34021172 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Plasma homocysteine levels ( 26519441 ) Red cell distribution width ( 32888494 27863252 ) Reticulocyte count ( 27863252 ) Reticulocyte fraction of red cells ( 27863252 )	No GWAS studies recorded
Interacting Genes		34 interacting genes: ARAP3 BCAR1 CAPZA1 CBL CBLB CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A RIN3 SH3GL2 SOS1 SOS2 SRC UBC UBE2I WTIP YES1	4 interacting genes: BRCA2 CD2AP NR3C1 WT1
Entrez ID		23607	126374
HPRD ID		05026	19007
Ensembl ID		ENSG00000198087	ENSG00000142279
Uniprot IDs		Q9Y5K6	A6NIX2
PDB IDs		2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23 4WCI 4X1V 7DS6 7DS8	Not available
GO Terms Enriched among Interactors		Phosphotyrosine Residue Binding Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol SH3 Domain Binding Cellular Response To Platelet-derived Growth Factor Stimulus Immune Effector Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Platelet-derived Growth Factor Cell-cell Junction Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Immune System Process Regulation Of ERBB Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Insulin Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Actin Filament Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Focal Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Natural Killer Cell Mediated Immunity T Cell Costimulation Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization Response To Growth Factor Membrane Raft Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Transport Cytoplasm Actin Cytoskeleton Organization Leukocyte Migration	Gonad Development Podocyte Differentiation Glomerulus Development Reproductive Structure Development Adrenal Gland Development Gland Development Cell Differentiation Involved In Kidney Development Reproductive Process Animal Organ Development Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Response To Transforming Growth Factor Beta Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Response To Hormone BRCA2-MAGE-D1 Complex Nuclear Glucocorticoid Receptor Activity Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Epithelial Tube Morphogenesis Male Gonad Development Mitotic Recombination-dependent Replication Fork Processing Protein-containing Complex Chromatin Organization Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Developmental Process Involved In Reproduction Kidney Development Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Cellular Developmental Process Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Wounding Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Renal Albumin Absorption Response To Glial Cell Derived Neurotrophic Factor Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Nuclear Receptor-mediated Corticosteroid Signaling Pathway Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Epithelium Development Double-stranded Methylated DNA Binding Transforming Growth Factor Beta1 Production Localization Of Cell Negative Regulation Of Multicellular Organismal Process Nuclear Ubiquitin Ligase Complex Regulation Of Neuron Apoptotic Process Steroid Hormone Binding