CD2AP and PDCD6IP

Number of citations of the paper that reports this interaction (PubMedID 17853893)
52

Data Source:
HPRD (in vitro)

		CD2AP	PDCD6IP
Description		CD2 associated protein	programmed cell death 6 interacting protein
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GO Annotations	Cellular Component	Fibrillar Center Ruffle Podosome Nuclear Envelope Lumen Cytoplasm Late Endosome Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Actin Cytoskeleton Axon Dendrite Growth Cone Cell Leading Edge Neuromuscular Junction Filamentous Actin Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Slit Diaphragm Cell Projection Neuron Projection Extracellular Exosome Anchoring Junction Cell Periphery	Immunological Synapse Extracellular Region Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Bicellular Tight Junction Focal Adhesion Membrane Melanosome Actomyosin Extracellular Exosome Anchoring Junction Endoplasmic Reticulum Exit Site Flemming Body Extracellular Vesicle
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding Clathrin Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	Protein Binding Proteinase Activated Receptor Binding Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Immunological Synapse Formation Kidney Development Liver Development Endothelium Development Lipid Metabolic Process Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Inflammatory Response Response To Oxidative Stress Actin Filament Organization Signal Transduction Cell Population Proliferation Male Gonad Development Protein Secretion Response To Wounding Response To Virus Gene Expression Protein Transport Cell Migration Actin Filament Polymerization Cell Differentiation Protein Catabolic Process Neuron Projection Development Rab Protein Signal Transduction Glomerulus Development Response To Insulin Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Actin Cytoskeleton Organization Maintenance Of Blood-brain Barrier Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Cell-cell Adhesion Mediated By Cadherin Cell-cell Junction Organization D-glucose Import Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Synaptic Plasticity Lymph Node Development Collateral Sprouting Positive Regulation Of Protein Secretion Synapse Organization T Cell Receptor Signaling Pathway Negative Regulation Of Small GTPase Mediated Signal Transduction Protein Heterooligomerization Cell Division Stress-activated MAPK Cascade Localization Of Cell Adipose Tissue Development Membrane Organization Protein-containing Complex Assembly ERK1 And ERK2 Cascade Response To Transforming Growth Factor Beta Podocyte Differentiation Renal Albumin Absorption Positive Regulation Of Protein Localization To Nucleus Response To Glial Cell Derived Neurotrophic Factor	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Nucleus Organization Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Protein Transport Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Maintenance Of Epithelial Cell Apical/basal Polarity Viral Budding Protein Homooligomerization Cell Division Midbody Abscission Bicellular Tight Junction Assembly Regulation Of Membrane Permeability Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Extracellular Exosome Biogenesis Regulation Of Mitotic Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Extracellular Exosome Assembly
Pathways		Nephrin family interactions	Budding and maturation of HIV virion Uptake and function of anthrax toxins RIPK1-mediated regulated necrosis Regulation of necroptotic cell death
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Family history of Alzheimer's disease ( 30617256) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Plasma homocysteine levels ( 26519441) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Neuroticism ( 27089181) Periodontitis (Mean PAL) ( 24024966) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Smoking status (ever vs never smokers) ( 30643258) Visceral adipose tissue adjusted for BMI ( 22589738) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		34 interacting genes: ARAP3 BCAR1 CAPZA1 CBL CBLB CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A RIN3 SH3GL2 SOS1 SOS2 SRC UBC UBE2I WTIP YES1	43 interacting genes: ARRDC1 ARRDC3 ATN1 CD2AP CEP55 CHMP4A CHMP4B CHMP4C CXCR1 DRD1 EGFR F2R GRB2 ITSN1 ITSN2 KEAP1 LRRN1 MAPK6 NEDD4L NEURL2 NUP155 PDCD6 PTK2B RAMP3 RNF10 RNF11 SDCBP SDCBP2 SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SH3RF1 SNCA SRC SUMO2 TAB1 TSG101 TTF2 VPS28 VPS37C WWP2 YES1
Entrez ID		23607	10015
HPRD ID		05026	06425
Ensembl ID		ENSG00000198087	ENSG00000170248
Uniprot IDs		Q9Y5K6	Q8WUM4
PDB IDs		2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23 4WCI 4X1V 7DS6 7DS8	2OEV 2OEW 2OEX 2OJQ 2R02 2R03 2R05 2XS1 2XS8 2ZNE 3C3O 3C3Q 3C3R 3E1R 3WUV 4JJY 5V3R 5WA1 6KP3
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol SH3 Domain Binding Cellular Response To Platelet-derived Growth Factor Stimulus Immune Effector Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Platelet-derived Growth Factor Cell-cell Junction Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Immune System Process Regulation Of ERBB Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Insulin Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Actin Filament Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Focal Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Natural Killer Cell Mediated Immunity T Cell Costimulation Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization Response To Growth Factor Membrane Raft Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Transport Cytoplasm Actin Cytoskeleton Organization Leukocyte Migration	Endosome Viral Budding Via Host ESCRT Complex Viral Budding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Vesicle-mediated Transport Multivesicular Body Assembly Multivesicular Body Organization Establishment Of Protein Localization Late Endosome To Vacuole Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Proteolysis Involved In Protein Catabolic Process Endocytosis Protein Transport Endosome Organization Cytoplasm Regulation Of Endocytosis Multivesicular Body Macromolecule Catabolic Process Biological Process Involved In Interaction With Host Macroautophagy Endosomal Transport Receptor-mediated Endocytosis Import Into Cell Midbody Abscission Cellular Localization Establishment Of Localization In Cell Regulation Of MAPK Cascade Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Intracellular Transport Viral Release From Host Cell Receptor Internalization Vesicle Organization Protein Metabolic Process Positive Regulation Of MAPK Cascade Viral Process Late Endosome Membrane ESCRT I Complex ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Plasma Membrane Synaptic Vesicle Endocytosis Cytokinetic Process Regulation Of Organelle Assembly
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