TDRD7 and MLH3

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		TDRD7	MLH3
Description		tudor domain containing 7	mutL homolog 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Chromatoid Body Ribonucleoprotein Granule P Granule	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Lens Morphogenesis In Camera-type Eye Spermatogenesis Post-transcriptional Regulation Of Gene Expression Cell Differentiation P Granule Organization PiRNA Processing Lens Fiber Cell Differentiation	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization
Pathways			Meiotic recombination
Drugs
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		25 interacting genes: ATXN2 BUB1 CABLES1 CCND1 CDK17 CDKN2A CTNNA1 DCC DLC1 FRAT1 FXR1 GABPB1 MAGEA8 MLH1 MLH3 MSH2 MUTYH NLGN3 NRAS ODC1 RNF10 SHANK3 STK11 TACC1 VHL	48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		23424	27030
HPRD ID		11626	05094
Ensembl ID		ENSG00000196116	ENSG00000119684
Uniprot IDs		Q8NHU6	Q2M1Z1 Q9UHC1
PDB IDs		3RCO
Enriched GO Terms of Interacting Partners?		Mismatch Repair Mismatched DNA Binding Regulation Of Nervous System Development ATP-dependent DNA Damage Sensor Activity Chiasma Regulation Of Neurogenesis Guanine/thymine Mispair Binding Positive Regulation Of Isotype Switching To IgA Isotypes Mismatch Repair Complex Centromeric DNA Binding MutSalpha Complex Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Regulation Of Developmental Process Positive Regulation Of Developmental Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Nucleus Apoptotic Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Cell Development Regulation Of Glutamate Receptor Signaling Pathway Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Synaptic Transmission, Glutamatergic Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Cell Differentiation Regulation Of Isotype Switching To IgG Isotypes Mammary Gland Epithelial Cell Proliferation Cellular Response To Stress Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Phase Transition Cell Division Organelle Organization Vocalization Behavior Negative Regulation Of Cell Population Proliferation Response To UV-B Intracellular Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Cell Development Cell Junction Assembly Isotype Switching Synaptonemal Complex Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Nervous System Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Nervous System Process Response To X-ray DNA Damage Response	Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration
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