TDRD7 and MUTYH

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		TDRD7	MUTYH
Description		tudor domain containing 7	mutY DNA glycosylase
Image
GO Annotations	Cellular Component	Cytoplasm Chromatoid Body Ribonucleoprotein Granule P Granule	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	RNA Binding MRNA Binding Protein Binding	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA Binding Catalytic Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Spermatogenesis Post-transcriptional Regulation Of Gene Expression Cell Differentiation P Granule Organization PiRNA Processing Lens Fiber Cell Differentiation	DNA Repair Base-excision Repair Mismatch Repair Response To Stress DNA Damage Response Depurination Negative Regulation Of Necroptotic Process
Pathways
Drugs
Diseases			Familial adenomatous polyposis
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Composite immunoglobulin trait (IgA/IgM) ( 28628107) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		25 interacting genes: ATXN2 BUB1 CABLES1 CCND1 CDK17 CDKN2A CTNNA1 DCC DLC1 FRAT1 FXR1 GABPB1 MAGEA8 MLH1 MLH3 MSH2 MUTYH NLGN3 NRAS ODC1 RNF10 SHANK3 STK11 TACC1 VHL	19 interacting genes: AGTRAP APEX1 BAAT CYLC2 FANCC HRAS LMNA LRSAM1 MSANTD3 MSH6 PCNA RPA1 RPA4 SEC61B SIRT6 SMAD1 TDRD7 TSTD2 XPA
Entrez ID		23424	4595
HPRD ID		11626	05380
Ensembl ID		ENSG00000196116	ENSG00000132781
Uniprot IDs		Q8NHU6	A0AAQ5BGW7 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 E9PP34 Q9UIF7
PDB IDs		3RCO	1X51 3N5N 8FAY
Enriched GO Terms of Interacting Partners?		Mismatch Repair Mismatched DNA Binding Regulation Of Nervous System Development ATP-dependent DNA Damage Sensor Activity Chiasma Regulation Of Neurogenesis Guanine/thymine Mispair Binding Positive Regulation Of Isotype Switching To IgA Isotypes Mismatch Repair Complex Centromeric DNA Binding MutSalpha Complex Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Regulation Of Developmental Process Positive Regulation Of Developmental Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Nucleus Apoptotic Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Cell Development Regulation Of Glutamate Receptor Signaling Pathway Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Synaptic Transmission, Glutamatergic Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Cell Differentiation Regulation Of Isotype Switching To IgG Isotypes Mammary Gland Epithelial Cell Proliferation Cellular Response To Stress Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Phase Transition Cell Division Organelle Organization Vocalization Behavior Negative Regulation Of Cell Population Proliferation Response To UV-B Intracellular Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Cell Development Cell Junction Assembly Isotype Switching Synaptonemal Complex Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Nervous System Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Nervous System Process Response To X-ray DNA Damage Response	Damaged DNA Binding Base-excision Repair DNA Repair Nucleotide-excision Repair DNA Replication Factor A Complex DNA Metabolic Process DNA Damage Response Chromosome, Telomeric Region Cellular Response To Stress Mismatch Repair Site Of Double-strand Break Response To Stress Response To UV MutLalpha Complex Binding Male Germ Cell Nucleus Chromosome Organization Nuclear Lamina Base-excision Repair, Gap-filling Response To Radiation DNA Recombination Telomere Maintenance Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Telomere Organization Protein Localization To Site Of Double-strand Break Response To Light Stimulus DNA Replication Protein Localization To Organelle Determination Of Adult Lifespan Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Telomere Maintenance Via Base-excision Repair Glycine N-choloyltransferase Activity Bile Acid Conjugation Meiotic Mismatch Repair Intrinsic Apoptotic Signaling Pathway Cellular Response To Radiation Protein Localization To Nucleus PCNA Complex Replisome Site Of DNA Damage Nucleotide-excision Repair, DNA Damage Recognition Endoplasmic Reticulum Sec Complex Histone H3K56 Deacetylase Activity, NAD-dependent Negative Regulation Of Cell Population Proliferation DNA-(abasic Site) Binding Nucleoplasm Double-stranded DNA Exodeoxyribonuclease Activity Deoxyribonuclease (pyrimidine Dimer) Activity
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