TDRD7 and TACC1

Number of citations of the paper that reports this interaction (PubMedID 14603251)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TDRD7	TACC1
Description		tudor domain containing 7	transforming acidic coiled-coil containing protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Chromatoid Body Ribonucleoprotein Granule P Granule	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Membrane Midbody
	Molecular Function	RNA Binding MRNA Binding Protein Binding	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Glucocorticoid Receptor Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Spermatogenesis Post-transcriptional Regulation Of Gene Expression Cell Differentiation P Granule Organization PiRNA Processing Lens Fiber Cell Differentiation	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Nuclear Migration Cerebral Cortex Development Positive Regulation Of DNA-templated Transcription Cell Division
Pathways
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Blond vs. brown/black hair color ( 30531825) Chronic mountain sickness ( 31417607) Midgestational circulating levels of PBDEs ( 28235828)
Interacting Genes		25 interacting genes: ATXN2 BUB1 CABLES1 CCND1 CDK17 CDKN2A CTNNA1 DCC DLC1 FRAT1 FXR1 GABPB1 MAGEA8 MLH1 MLH3 MSH2 MUTYH NLGN3 NRAS ODC1 RNF10 SHANK3 STK11 TACC1 VHL	20 interacting genes: AURKA AURKB BTRC ERCC4 FAM50B HTT ITSN2 KAT2A KDM1A LSM7 MEMO1 SH2D4A SNRPG STX5 TDRD7 THAP12 THRA YEATS4 ZFHX3 ZNF48
Entrez ID		23424	6867
HPRD ID		11626	10391
Ensembl ID		ENSG00000196116	ENSG00000147526
Uniprot IDs		Q8NHU6	B7Z3G3 E5RFM9 E7ET87 E7EVI4 O75410
PDB IDs		3RCO
Enriched GO Terms of Interacting Partners?		Mismatch Repair Mismatched DNA Binding Regulation Of Nervous System Development ATP-dependent DNA Damage Sensor Activity Chiasma Regulation Of Neurogenesis Guanine/thymine Mispair Binding Positive Regulation Of Isotype Switching To IgA Isotypes Mismatch Repair Complex Centromeric DNA Binding MutSalpha Complex Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Regulation Of Developmental Process Positive Regulation Of Developmental Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Nucleus Apoptotic Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Cell Development Regulation Of Glutamate Receptor Signaling Pathway Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Synaptic Transmission, Glutamatergic Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Cell Differentiation Regulation Of Isotype Switching To IgG Isotypes Mammary Gland Epithelial Cell Proliferation Cellular Response To Stress Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Phase Transition Cell Division Organelle Organization Vocalization Behavior Negative Regulation Of Cell Population Proliferation Response To UV-B Intracellular Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Cell Development Cell Junction Assembly Isotype Switching Synaptonemal Complex Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Nervous System Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Nervous System Process Response To X-ray DNA Damage Response	Spliceosomal Tri-snRNP Complex Chromosome Passenger Complex Nucleoplasm Nucleus Regulation Of DNA Metabolic Process Cellular Response To UV Regulation Of Microtubule-based Process U2-type Prespliceosome P Granule Cellular Response To Light Stimulus Microtubule Cytoskeleton Organization Involved In Mitosis U12-type Spliceosomal Complex Regulation Of Signal Transduction By P53 Class Mediator Spindle Midzone Protein Serine/threonine/tyrosine Kinase Activity Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Response To UV Cellular Response To Radiation Regulation Of Cell Division Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Regulation Of Protein Stability Peptide Glutaryltransferase Activity U4/U6 X U5 Tri-snRNP Complex Spindle Microtubule Mitotic Spindle Pole Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Nucleobase-containing Compound Metabolic Process Midbody Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Locomotor Rhythm Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Regulation Of Organelle Organization Regulation Of Centrosome Cycle Regulation Of DNA Repair Chromatin Organization Histone H3K9 Acetyltransferase Activity Protein Destabilization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity U2-type Precatalytic Spliceosome Cell Cycle G2/M Phase Transition Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
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