TDRD7 and FRAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TDRD7	FRAT1
Description		tudor domain containing 7	FRAT regulator of Wnt signaling pathway 1
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GO Annotations	Cellular Component	Cytoplasm Chromatoid Body Ribonucleoprotein Granule P Granule	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Binding MRNA Binding Protein Binding	Protein Binding Molecular Function Inhibitor Activity
	Biological Process	Lens Morphogenesis In Camera-type Eye Spermatogenesis Post-transcriptional Regulation Of Gene Expression Cell Differentiation P Granule Organization PiRNA Processing Lens Fiber Cell Differentiation	Wnt Signaling Pathway Regulation Of Protein Export From Nucleus Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		25 interacting genes: ATXN2 BUB1 CABLES1 CCND1 CDK17 CDKN2A CTNNA1 DCC DLC1 FRAT1 FXR1 GABPB1 MAGEA8 MLH1 MLH3 MSH2 MUTYH NLGN3 NRAS ODC1 RNF10 SHANK3 STK11 TACC1 VHL	13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7
Entrez ID		23424	10023
HPRD ID		11626	03935
Ensembl ID		ENSG00000196116	ENSG00000165879
Uniprot IDs		Q8NHU6	Q92837
PDB IDs		3RCO	1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4
Enriched GO Terms of Interacting Partners?		Mismatch Repair Mismatched DNA Binding Regulation Of Nervous System Development ATP-dependent DNA Damage Sensor Activity Chiasma Regulation Of Neurogenesis Guanine/thymine Mispair Binding Positive Regulation Of Isotype Switching To IgA Isotypes Mismatch Repair Complex Centromeric DNA Binding MutSalpha Complex Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Regulation Of Developmental Process Positive Regulation Of Developmental Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Nucleus Apoptotic Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Cell Development Regulation Of Glutamate Receptor Signaling Pathway Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Synaptic Transmission, Glutamatergic Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Cell Differentiation Regulation Of Isotype Switching To IgG Isotypes Mammary Gland Epithelial Cell Proliferation Cellular Response To Stress Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Phase Transition Cell Division Organelle Organization Vocalization Behavior Negative Regulation Of Cell Population Proliferation Response To UV-B Intracellular Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Cell Development Cell Junction Assembly Isotype Switching Synaptonemal Complex Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Nervous System Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Nervous System Process Response To X-ray DNA Damage Response	Wnt Signalosome
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