CTSD and CCL21

Number of citations of the paper that reports this interaction (PMID 12651610)
10

Data Source:
HPRD (in vitro)

		CTSD	CCL21
Gene Name		cathepsin D	chemokine (C-C motif) ligand 21
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Extracellular Matrix Melanosome Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding	Chemokine Activity CCR7 Chemokine Receptor Binding Chemokine Receptor Binding
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process	Establishment Of T Cell Polarity Immunological Synapse Formation Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Ruffle Organization Activation Of Rho GTPase Activity Positive Regulation Of Cell Adhesion Mediated By Integrin Response To Prostaglandin E Mesangial Cell-matrix Adhesion Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly
Pathways		Peptide hormone metabolism Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Degradation of the extracellular matrix Adaptive Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Insulin Regular Insulin, porcine S-Methylcysteine Alpha-D-Mannose 1h-Benoximidazole-2-Carboxylic Acid N-Aminoethylmorpholine 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
Diseases
GWAS			Rheumatoid arthritis ( 18794853 20453842)
Protein-Protein Interactions		18 interactors: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 IGF2R IGFBP3 IGFBP4 INS MAPK1 PSAP SERPINA4 SHBG SLC2A4 TG	10 interactors: ACKR2 ACKR4 CCR10 CCR7 CTSD CXCL13 GOT2 IGFBP7 UBQLN4 VCAN
Entrez ID		1509	6366
HPRD ID		00291	04113
Ensembl ID		ENSG00000117984	ENSG00000137077
Uniprot IDs		P07339	O00585 Q6ICR7
PDB IDs		1LYA 1LYB 1LYW	2L4N
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Developmental Process Defense Response Regulation Of Proteolysis Cell Activation Regulation Of Peptidase Activity Regulation Of Phosphorylation Anatomical Structure Development Regulation Of MAPK Cascade Negative Regulation Of Proteolysis Regulation Of Phosphorus Metabolic Process Cell Differentiation Negative Regulation Of Protein Processing Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Processing Platelet Activation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Platelet Degranulation Positive Regulation Of Phosphorylation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Endopeptidase Activity System Development Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Peptidase Activity Response To Hormone Regulation Of Apoptotic Process Wound Healing Regulation Of Glucose Metabolic Process Regulation Of Growth Regulation Of Cell Death Regulation Of Protein Phosphorylation Regulation Of Cell Growth Organ Development Response To Wounding Extracellular Matrix Organization Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Extracellular Structure Organization Multicellular Organismal Development Cell Adhesion Regulation Of Protein Kinase Activity	Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Locomotion Response To Cytokine Response To Organic Substance Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Neutrophil Activation Cellular Response To Organic Substance Cytosolic Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Lymphocyte Migration Immune System Process Immune Response Regulation Of Humoral Immune Response Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Activation Of Ras GTPase Activity Positive Regulation Of Leukocyte Chemotaxis Receptor-mediated Endocytosis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-C Motif) Ligand 19 Signaling Pathway Lymphocyte Chemotaxis Across High Endothelial Venule Positive Regulation Of Immunological Synapse Formation Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Lymphocyte Migration Into Lymph Node Response To External Stimulus Cellular Metal Ion Homeostasis Positive Regulation Of Leukocyte Migration Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Interleukin-12 Secretion Activation Of Rap GTPase Activity Positive Regulation Of T Cell Costimulation Leukocyte Chemotaxis Leukocyte Activation Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Cell Recognition Positive Regulation Of Behavior
Tagcloud ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Difference) ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Intersection) ?