CTSD and IGFBP4

Number of citations of the paper that reports this interaction (PMID 9275067)
13

Data Source:
HPRD (in vitro)

		CTSD	IGFBP4
Gene Name		cathepsin D	insulin-like growth factor binding protein 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Extracellular Matrix Melanosome Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding	Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process	Skeletal System Development Regulation Of Cell Growth DNA Metabolic Process Inflammatory Response Signal Transduction Cell Proliferation Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation
Pathways		Peptide hormone metabolism Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Degradation of the extracellular matrix Adaptive Immune System	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Insulin Regular Insulin, porcine S-Methylcysteine Alpha-D-Mannose 1h-Benoximidazole-2-Carboxylic Acid N-Aminoethylmorpholine 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
Diseases
GWAS			Height ( 23563607)
Protein-Protein Interactions		18 interactors: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 IGF2R IGFBP3 IGFBP4 INS MAPK1 PSAP SERPINA4 SHBG SLC2A4 TG	8 interactors: CTSD HK3 IGF1 IGF2 KDM1A PAPPA SUV39H1 TF
Entrez ID		1509	3487
HPRD ID		00291	00900
Ensembl ID		ENSG00000117984	ENSG00000141753
Uniprot IDs		P07339	P22692
PDB IDs		1LYA 1LYB 1LYW	1WQJ 2DSP 2DSQ 2DSR
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Developmental Process Defense Response Regulation Of Proteolysis Cell Activation Regulation Of Peptidase Activity Regulation Of Phosphorylation Anatomical Structure Development Regulation Of MAPK Cascade Negative Regulation Of Proteolysis Regulation Of Phosphorus Metabolic Process Cell Differentiation Negative Regulation Of Protein Processing Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Processing Platelet Activation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Platelet Degranulation Positive Regulation Of Phosphorylation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Endopeptidase Activity System Development Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Peptidase Activity Response To Hormone Regulation Of Apoptotic Process Wound Healing Regulation Of Glucose Metabolic Process Regulation Of Growth Regulation Of Cell Death Regulation Of Protein Phosphorylation Regulation Of Cell Growth Organ Development Response To Wounding Extracellular Matrix Organization Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Extracellular Structure Organization Multicellular Organismal Development Cell Adhesion Regulation Of Protein Kinase Activity	Platelet Degranulation Exocrine Pancreas Development Positive Regulation Of Hormone Biosynthetic Process Blood Coagulation Hemostasis Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Body Fluid Levels Positive Regulation Of Activated T Cell Proliferation Wound Healing Platelet Activation Regulation Of Hormone Biosynthetic Process Response To Wounding Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Hormone Metabolic Process Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Muscle Cell Differentiation Positive Regulation Of Neural Precursor Cell Proliferation Exocytosis Exocrine System Development Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of T Cell Proliferation Regulation Of DNA Binding Pancreas Development Muscle Structure Development Secretion By Cell Regulation Of Glucose Metabolic Process Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Secretion Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Regulation Of T Cell Proliferation Digestive System Development Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Activation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Negative Regulation Of Oocyte Development Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Muscle Cell Development
Tagcloud ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	absence added alteration autocrine concluded depend describes differ driven hormones igfir inducible mcf membranes mi7 mitogenic oestrogen onto overcome polycarbonate result secreted serum steroid transfected untransfected vector would
Tagcloud (Difference) ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	absence added alteration autocrine concluded depend describes differ driven hormones igfir inducible mcf membranes mi7 mitogenic oestrogen onto overcome polycarbonate result secreted serum steroid transfected untransfected vector would
Tagcloud (Intersection) ?