CTSD and CSTB

Number of citations of the paper that reports this interaction (PubMedID 3261170)
0

Data Source:
HPRD (in vitro)

		CTSD	CSTB
Description		cathepsin D	cystatin B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Cytosol Endosome Membrane Extracellular Matrix Endosome Lumen Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Extracellular Matrix Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Endopeptidase Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity Aspartic-type Peptidase Activity	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Autophagosome Assembly Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Insulin Receptor Recycling Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Execution Phase Of Apoptosis Insulin Catabolic Process	Adult Locomotory Behavior Negative Regulation Of Proteolysis
Pathways		Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Insulin receptor recycling Estrogen-dependent gene expression	Neutrophil degranulation
Drugs		S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid 2-Morpholinoethylamine 5-Amino-6-cyclohexyl-4-hydroxy-2-isobutyl-hexanoic acid CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE	Cupric Chloride
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		25 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NEAT1 NLGN3 OGT PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG	8 interacting genes: CST3 CTSB CTSD CTSH CTSL ECT2 RAD21 SPRY2
Entrez ID		1509	1476
HPRD ID		00291	03091
Ensembl ID		ENSG00000117984	ENSG00000160213
Uniprot IDs		P07339 V9HWI3	P04080 Q76LA1
PDB IDs		1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9	1STF 2OCT 4N6V
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Region Endoplasmic Reticulum Lumen Regulation Of Small Molecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Synaptic Transmission Insulin-like Growth Factor II Binding Regulation Of MAPK Cascade Cognition Regulation Of Protein Metabolic Process Protease Binding Insulin-like Growth Factor Binding Regulation Of Phosphorus Metabolic Process Learning Or Memory Type B Pancreatic Cell Proliferation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process Regulation Of Developmental Process Regulation Of Synaptic Plasticity Amyloid Fibril Formation Response To Cytokine Regulation Of Cellular Component Organization Microglial Cell Activation Response To Peptide Regulation Of Multicellular Organismal Process Regulation Of Glucose Metabolic Process Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Regulation Of Signaling Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cell-cell Signaling Positive Regulation Of Intracellular Signal Transduction Peptidase Inhibitor Activity Main Axon Cellular Response To Oxygen-containing Compound Signaling Negative Regulation Of Protein Catabolic Process Ficolin-1-rich Granule Lumen Cell Communication Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of MAPK Cascade Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Proteolysis	Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Ficolin-1-rich Granule Lumen Extracellular Matrix Endolysosome Lumen Tertiary Granule Lumen Lysosome Regulation Of Extracellular Matrix Organization Collagen Binding Collagen Metabolic Process Endopeptidase Activity Proteoglycan Binding Antigen Processing And Presentation Cysteine-type Peptidase Activity Regulation Of Apoptotic Process Lung Morphogenesis Peptidase Activity Regulation Of Programmed Cell Death Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Zymogen Activation Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Regulation Of Collagen Metabolic Process Antigen Processing And Presentation Of Exogenous Antigen Tissue Regeneration Response To Polyamine Macromolecule Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process ERK1 And ERK2 Cascade HLA-A Specific Activating MHC Class I Receptor Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Cellular Developmental Process Antigen Processing And Presentation Of Peptide Antigen Extracellular Exosome Extracellular Region Regulation Of Tissue Remodeling Multicellular Organismal Locomotion Negative Regulation Of Blood Vessel Remodeling Cellular Response To Hormone Stimulus Aspartic-type Peptidase Activity Kininogen Binding Enkephalin Processing Lung Growth Extracellular Space Lysosomal Lumen
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