CTSD and NLGN3

Number of citations of the paper that reports this interaction (PubMedID 25464930)
0

Data Source:
BioGRID (two hybrid)

		CTSD	NLGN3
Description		cathepsin D	neuroligin 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Cytosol Endosome Membrane Extracellular Matrix Endosome Lumen Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Plasma Membrane Cell Surface Membrane Endocytic Vesicle Synapse Postsynaptic Membrane Excitatory Synapse Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse
	Molecular Function	Endopeptidase Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity Aspartic-type Peptidase Activity	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Autophagosome Assembly Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Insulin Receptor Recycling Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Execution Phase Of Apoptosis Insulin Catabolic Process	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Receptor-mediated Endocytosis Cell Adhesion Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Inhibitory Postsynaptic Potential Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Insulin receptor recycling Estrogen-dependent gene expression	Neurexins and neuroligins Neurexins and neuroligins
Drugs		S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid 2-Morpholinoethylamine 5-Amino-6-cyclohexyl-4-hydroxy-2-isobutyl-hexanoic acid CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Prostate cancer ( 25217961)
Interacting Genes		25 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NEAT1 NLGN3 OGT PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG	65 interacting genes: AKT1 ALPP AP2A2 APC2 ATF4 ATXN1 C1orf122 C1QA CCAR2 CGB3 COBL CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFEMP1 EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 HIVEP1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12P PICK1 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 RBFOX2 SPAG5 SPINT1 SSR4 TDRD7 TLE5 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1
Entrez ID		1509	54413
HPRD ID		00291	02275
Ensembl ID		ENSG00000117984	ENSG00000196338
Uniprot IDs		P07339 V9HWI3	A0A8I5KSB7 A0A8I5QJH8 B7Z3P8 Q4G160 Q9NZ94 X5D2P6 X5D7L6 X5DNV3
PDB IDs		1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9	8GS3
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Region Endoplasmic Reticulum Lumen Regulation Of Small Molecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Synaptic Transmission Insulin-like Growth Factor II Binding Regulation Of MAPK Cascade Cognition Regulation Of Protein Metabolic Process Protease Binding Insulin-like Growth Factor Binding Regulation Of Phosphorus Metabolic Process Learning Or Memory Type B Pancreatic Cell Proliferation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process Regulation Of Developmental Process Regulation Of Synaptic Plasticity Amyloid Fibril Formation Response To Cytokine Regulation Of Cellular Component Organization Microglial Cell Activation Response To Peptide Regulation Of Multicellular Organismal Process Regulation Of Glucose Metabolic Process Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Regulation Of Signaling Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cell-cell Signaling Positive Regulation Of Intracellular Signal Transduction Peptidase Inhibitor Activity Main Axon Cellular Response To Oxygen-containing Compound Signaling Negative Regulation Of Protein Catabolic Process Ficolin-1-rich Granule Lumen Cell Communication Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of MAPK Cascade Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Proteolysis	Receptor Clustering Neuroligin Family Protein Binding Kinase Binding Protein Localization To Cell Junction Vocalization Behavior Social Behavior Protein Localization To Synapse Female Pregnancy Protein Localization To Membrane Cell-cell Adhesion Neuron Cell-cell Adhesion Receptor Localization To Synapse Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Cellular Response To Metal Ion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway GDF15-GFRAL Signaling Pathway Somite Specification Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Localization Within Membrane Ionotropic Glutamate Receptor Binding NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Negative Regulation Of Signal Transduction Neuromuscular Junction Postsynapse Response To Metal Ion Negative Regulation Of Apoptotic Signaling Pathway Postsynaptic Membrane Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Learning Vocal Learning Cell Adhesion Cell-cell Signaling GMP Kinase Activity Postsynaptic Membrane Organization Neurotransmitter Secretion Observational Learning Cellular Localization Learning Or Memory Protein Kinase Inhibitor Activity Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway PERK-mediated Unfolded Protein Response GDP Metabolic Process
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