CTSD and PSAP

Number of citations of the paper that reports this interaction (PMID 12083803)
5

Data Source:
HPRD (in vivo)

		CTSD	PSAP
Gene Name		cathepsin D	prosaposin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Extracellular Matrix Melanosome Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleoplasm Nucleolus Mitochondrion Lysosomal Membrane Golgi Apparatus Integral Component Of Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding	Protein Binding Enzyme Activator Activity Lipid Binding
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process	Platelet Degranulation Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Lipid Transport Blood Coagulation Regulation Of Lipid Metabolic Process Platelet Activation Positive Regulation Of Catalytic Activity Regulation Of MAPK Cascade Small Molecule Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Cellular Response To Organic Substance
Pathways		Peptide hormone metabolism Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Degradation of the extracellular matrix Adaptive Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Peptide ligand-binding receptors Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation
Drugs		Insulin Regular Insulin, porcine S-Methylcysteine Alpha-D-Mannose 1h-Benoximidazole-2-Carboxylic Acid N-Aminoethylmorpholine 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE	Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases
GWAS
Protein-Protein Interactions		18 interactors: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 IGF2R IGFBP3 IGFBP4 INS MAPK1 PSAP SERPINA4 SHBG SLC2A4 TG	14 interactors: BACE1 BRCA1 CD1B CELSR1 COPS6 CTSD GBA MAFF SGK223 SMAD2 SMAD9 UBE3A USP4 ZBED1
Entrez ID		1509	5660
HPRD ID		00291	01460
Ensembl ID		ENSG00000117984	ENSG00000197746
Uniprot IDs		P07339	P07602
PDB IDs		1LYA 1LYB 1LYW	1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Developmental Process Defense Response Regulation Of Proteolysis Cell Activation Regulation Of Peptidase Activity Regulation Of Phosphorylation Anatomical Structure Development Regulation Of MAPK Cascade Negative Regulation Of Proteolysis Regulation Of Phosphorus Metabolic Process Cell Differentiation Negative Regulation Of Protein Processing Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Processing Platelet Activation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Platelet Degranulation Positive Regulation Of Phosphorylation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Endopeptidase Activity System Development Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Peptidase Activity Response To Hormone Regulation Of Apoptotic Process Wound Healing Regulation Of Glucose Metabolic Process Regulation Of Growth Regulation Of Cell Death Regulation Of Protein Phosphorylation Regulation Of Cell Growth Organ Development Response To Wounding Extracellular Matrix Organization Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Extracellular Structure Organization Multicellular Organismal Development Cell Adhesion Regulation Of Protein Kinase Activity	Regulation Of Protein Ubiquitination Androgen Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Histone H4-K20 Methylation Sperm Entry Positive Regulation Of Histone H4-K16 Acetylation Protein Localization Involved In Establishment Of Planar Polarity Intracellular Steroid Hormone Receptor Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Cellular Protein Modification Process Protein Metabolic Process Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Establishment Of Body Hair Planar Orientation Positive Regulation Of Histone H3-K9 Acetylation Lateral Sprouting Involved In Lung Morphogenesis Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Glucosylceramide Catabolic Process Urogenital System Development Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Organ Growth Cellular Response To Tumor Necrosis Factor Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Zygotic Specification Of Dorsal/ventral Axis Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Protein Modification By Small Protein Removal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Mesonephros Development Response To Tumor Necrosis Factor Glucosylceramide Metabolic Process Cellular Response To Indole-3-methanol Establishment Of Planar Polarity Of Embryonic Epithelium Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Mesoderm Development Negative Regulation Of Centriole Replication Primary MiRNA Processing Sphingosine Biosynthetic Process Embryo Development Kidney Epithelium Development Dosage Compensation By Inactivation Of X Chromosome Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Sphingoid Biosynthetic Process
Tagcloud ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	ac acinar adenocarcinoma cdx2 cea ck20 ck7 dac debated erg gleason hmwck immunomarkers ki lysozyme morphotypes overlap p16 p504s p63 patchy pax prolactin prostatic prostein psma slides villin
Tagcloud (Difference) ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	ac acinar adenocarcinoma cdx2 cea ck20 ck7 dac debated erg gleason hmwck immunomarkers ki lysozyme morphotypes overlap p16 p504s p63 patchy pax prolactin prostatic prostein psma slides villin
Tagcloud (Intersection) ?