CTSD and BGLAP

Number of citations of the paper that reports this interaction (PMID 9076588)
4

Data Source:
HPRD (in vivo)

		CTSD	BGLAP
Gene Name		cathepsin D	bone gamma-carboxyglutamate (gla) protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Extracellular Matrix Melanosome Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Rough Endoplasmic Reticulum Golgi Apparatus Dendrite Membrane-bounded Vesicle Perikaryon
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding	Structural Molecule Activity Calcium Ion Binding Structural Constituent Of Bone Hydroxyapatite Binding
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process	Skeletal System Development Osteoblast Differentiation Osteoblast Development Cell Adhesion Cell Aging Response To Mechanical Stimulus Response To Gravity Response To Zinc Ion Response To Activity Bone Mineralization Regulation Of Bone Mineralization Response To Vitamin K Response To Vitamin D Response To Testosterone Response To Hydroxyisoflavone Odontogenesis Response To Drug Response To Estrogen Regulation Of Bone Resorption Response To Ethanol Regulation Of Osteoclast Differentiation Response To Glucocorticoid Bone Development Cellular Response To Vitamin D Cellular Response To Growth Factor Stimulus
Pathways		Peptide hormone metabolism Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Degradation of the extracellular matrix Adaptive Immune System
Drugs		Insulin Regular Insulin, porcine S-Methylcysteine Alpha-D-Mannose 1h-Benoximidazole-2-Carboxylic Acid N-Aminoethylmorpholine 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE	Menadione Phytonadione Gamma-Carboxy-Glutamic Acid Gallium nitrate
Diseases
GWAS			mean corpuscular hemoglobin concentration ( 20139978)
Protein-Protein Interactions		18 interactors: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 IGF2R IGFBP3 IGFBP4 INS MAPK1 PSAP SERPINA4 SHBG SLC2A4 TG	5 interactors: CTSB CTSD CTSH CTSS GGCX
Entrez ID		1509	632
HPRD ID		00291	00205
Ensembl ID		ENSG00000117984
Uniprot IDs		P07339	P02818
PDB IDs		1LYA 1LYB 1LYW
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Developmental Process Defense Response Regulation Of Proteolysis Cell Activation Regulation Of Peptidase Activity Regulation Of Phosphorylation Anatomical Structure Development Regulation Of MAPK Cascade Negative Regulation Of Proteolysis Regulation Of Phosphorus Metabolic Process Cell Differentiation Negative Regulation Of Protein Processing Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Processing Platelet Activation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Platelet Degranulation Positive Regulation Of Phosphorylation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Endopeptidase Activity System Development Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Peptidase Activity Response To Hormone Regulation Of Apoptotic Process Wound Healing Regulation Of Glucose Metabolic Process Regulation Of Growth Regulation Of Cell Death Regulation Of Protein Phosphorylation Regulation Of Cell Growth Organ Development Response To Wounding Extracellular Matrix Organization Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Extracellular Structure Organization Multicellular Organismal Development Cell Adhesion Regulation Of Protein Kinase Activity	Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Antigen Processing And Presentation Extracellular Matrix Organization Extracellular Structure Organization Immune Response-regulating Signaling Pathway Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cellular Response To Hormone Stimulus Catabolic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune System Process Activation Of Innate Immune Response Basement Membrane Disassembly Neuropeptide Catabolic Process Regulation Of Immune Response Positive Regulation Of Innate Immune Response Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Response To Hormone Protein Metabolic Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response Bradykinin Catabolic Process Adaptive Immune Response Immune Response Regulation Of Immune System Process Peptidyl-glutamic Acid Carboxylation T Cell Mediated Cytotoxicity Surfactant Homeostasis Peptide Catabolic Process Chemical Homeostasis Within A Tissue ERK1 And ERK2 Cascade Decidualization Basement Membrane Organization Cellular Response To Organic Substance Protein Destabilization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Maternal Placenta Development Leukocyte Mediated Cytotoxicity
Tagcloud ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	a2 a5 alkaline altered annexin annexins anxa2 anxa5 col1a1 else fibrinolysis generate ibsp knock knockdown mineralizing osteoblasts osteogenesis osteogenic osteoprogenitor programming psiren rafts responsiveness runx2 shrna si stat6 vesicles
Tagcloud (Difference) ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	a2 a5 alkaline altered annexin annexins anxa2 anxa5 col1a1 else fibrinolysis generate ibsp knock knockdown mineralizing osteoblasts osteogenesis osteogenic osteoprogenitor programming psiren rafts responsiveness runx2 shrna si stat6 vesicles
Tagcloud (Intersection) ?