CTSD and BGLAP

Number of citations of the paper that reports this interaction (PubMedID 9076588)
0

Data Source:
HPRD (in vivo)

		CTSD	BGLAP
Description		cathepsin D	bone gamma-carboxyglutamate protein
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Cytosol Endosome Membrane Extracellular Matrix Endosome Lumen Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Dendrite Vesicle Cell Projection Perikaryon
	Molecular Function	Endopeptidase Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity Aspartic-type Peptidase Activity	Hormone Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Bone Hydroxyapatite Binding Metal Ion Binding
	Biological Process	Autophagosome Assembly Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Insulin Receptor Recycling Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Execution Phase Of Apoptosis Insulin Catabolic Process	Skeletal System Development Ossification Osteoblast Differentiation Positive Regulation Of Neurotransmitter Secretion Cell Adhesion Signal Transduction Brain Development Learning Or Memory Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Gravity Response To Zinc Ion Response To Activity Bone Mineralization Regulation Of Bone Mineralization Biomineral Tissue Development Response To Nutrient Levels Response To Vitamin K Response To Insulin Cellular Response To Insulin Stimulus Response To Vitamin D Response To Testosterone Response To Hydroxyisoflavone Cellular Response To Zinc Ion Starvation Response To Macrophage Colony-stimulating Factor Glucose Homeostasis Response To Estrogen Type B Pancreatic Cell Proliferation Regulation Of Bone Resorption Response To Ethanol Regulation Of Osteoclast Differentiation System Development Stem Cell Differentiation Cognition Response To Glucocorticoid Bone Development Cellular Response To Vitamin D Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Bone Development Regulation Of Testosterone Biosynthetic Process
Pathways		Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Insulin receptor recycling Estrogen-dependent gene expression	Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins RUNX2 regulates osteoblast differentiation
Drugs		S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid 2-Morpholinoethylamine 5-Amino-6-cyclohexyl-4-hydroxy-2-isobutyl-hexanoic acid CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE	Menadione Phylloquinone gamma-carboxy-L-glutamic acid Gallium nitrate
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)	Estimated glomerular filtration rate ( 30604766) Mean corpuscular hemoglobin concentration ( 20139978) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) White matter hyperintensity burden ( 25663218)
Interacting Genes		25 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NEAT1 NLGN3 OGT PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG	6 interacting genes: ASPH CTSB CTSD CTSH CTSS GGCX
Entrez ID		1509	632
HPRD ID		00291	00205
Ensembl ID		ENSG00000117984	ENSG00000242252
Uniprot IDs		P07339 V9HWI3	P02818
PDB IDs		1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9	8XS1 9BUR 9BUX
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Region Endoplasmic Reticulum Lumen Regulation Of Small Molecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Synaptic Transmission Insulin-like Growth Factor II Binding Regulation Of MAPK Cascade Cognition Regulation Of Protein Metabolic Process Protease Binding Insulin-like Growth Factor Binding Regulation Of Phosphorus Metabolic Process Learning Or Memory Type B Pancreatic Cell Proliferation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process Regulation Of Developmental Process Regulation Of Synaptic Plasticity Amyloid Fibril Formation Response To Cytokine Regulation Of Cellular Component Organization Microglial Cell Activation Response To Peptide Regulation Of Multicellular Organismal Process Regulation Of Glucose Metabolic Process Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Regulation Of Signaling Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cell-cell Signaling Positive Regulation Of Intracellular Signal Transduction Peptidase Inhibitor Activity Main Axon Cellular Response To Oxygen-containing Compound Signaling Negative Regulation Of Protein Catabolic Process Ficolin-1-rich Granule Lumen Cell Communication Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of MAPK Cascade Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Proteolysis	Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Ficolin-1-rich Granule Lumen Response To Thyroid Hormone Tertiary Granule Lumen Endolysosome Lumen Endopeptidase Activity Antigen Processing And Presentation Extracellular Matrix Peptidase Activity Proteoglycan Binding Lysosome Cysteine-type Peptidase Activity Positive Regulation Of Cation Channel Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Protein Maturation Cellular Response To Hormone Stimulus Collagen Metabolic Process Collagen Binding Antigen Processing And Presentation Of Peptide Antigen Proteolysis Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity HLA-A Specific Activating MHC Class I Receptor Activity Gamma-glutamyl Carboxylase Activity Lysosomal Lumen Melanosome Peptidyl-aspartic Acid 3-dioxygenase Activity Positive Regulation Of Cation Transmembrane Transport Extracellular Space Aspartic-type Peptidase Activity Kininogen Binding Vitamin Binding Negative Regulation Of Bone Development Positive Regulation Of Monoatomic Ion Transmembrane Transport Protein Metabolic Process Response To Hormone Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Hydrolase Activity Response To Odorant Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Basement Membrane Disassembly Negative Regulation Of Testosterone Biosynthetic Process
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