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SOS1 and GAB1
Number of citations of the paper that reports this interaction (PubMedID
11707404
)
60
Data Source:
BioGRID
(imaging technique)
HPRD
(in vitro)
SOS1
GAB1
Description
SOS Ras/Rac guanine nucleotide exchange factor 1
GRB2 associated binding protein 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Neuronal Cell Body
Glutamatergic Synapse
GTPase Complex
Cytoplasm
Cytosol
Cell-cell Junction
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Protein Heterodimerization Activity
Molecular Condensate Scaffold Activity
Protein Binding
Signaling Adaptor Activity
Biological Process
B Cell Homeostasis
Hair Follicle Development
Lymphocyte Homeostasis
Response To Ischemia
Heart Morphogenesis
Cardiac Atrium Morphogenesis
Pericardium Morphogenesis
Regulation Of Transcription By RNA Polymerase II
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase-mediated Signal Transduction
Ras Protein Signal Transduction
Vitellogenesis
Axon Guidance
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Schwann Cell Development
Cytokine-mediated Signaling Pathway
Regulation Of T Cell Differentiation In Thymus
Multicellular Organism Growth
Fc-epsilon Receptor Signaling Pathway
T Cell Activation
Regulation Of Cell Population Proliferation
Regulation Of T Cell Proliferation
Myelination
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Blood Vessel Morphogenesis
B Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Small GTPase Mediated Signal Transduction
Roof Of Mouth Development
Eyelid Development In Camera-type Eye
Heart Trabecula Morphogenesis
Midbrain Morphogenesis
Regulation Of Pro-B Cell Differentiation
Angiogenesis
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Intracellular Signal Transduction
Endothelial Cell Chemotaxis
Vascular Endothelial Growth Factor Signaling Pathway
Vasodilation
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Mechanical Stimulus
Pathways
SOS-mediated signalling
SOS-mediated signalling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Signalling to RAS
Signalling to RAS
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
NRAGE signals death through JNK
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
GRB2:SOS provides linkage to MAPK signaling for Integrins
NCAM signaling for neurite out-growth
G alpha (12/13) signalling events
Activation of RAC1
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
MET activates RAS signaling
RET signaling
Interleukin-15 signaling
RAC1 GTPase cycle
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
Interleukin receptor SHC signaling
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Potential therapeutics for SARS
Signaling by CSF1 (M-CSF) in myeloid cells
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Signaling by LTK
PI3K Cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PIP3 activates AKT signaling
GAB1 signalosome
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
MET activates PTPN11
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Aseptic loosening in total joint arthroplasty (
31791832
)
Corticobasal degeneration (
26077951
)
Sensorimotor dexterity (
31596458
)
Asthma (
21804548
)
Diastolic blood pressure (
27841878
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Height (
31562340
)
Malaria (
31844061
)
Systolic blood pressure (
27841878
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Interacting Genes
56 interacting genes:
ABI1
ABI3
ANXA2
ATP6V1E1
BIN1
CAV1
CD19
CD2AP
COPS3
CRK
CRKL
CSF1R
EGFR
EPS8
EPS8L1
EPS8L2
ERBB2
ERBB3
ESR1
FGFR1
FRS2
FYN
GAB1
GRAP
GRB2
HCK
HDLBP
HRAS
ITSN1
ITSN2
LAT2
LCK
MAPK1
MAPK3
MUC1
NCK1
NCK2
PACSIN1
PACSIN3
PIK3R2
PLCG1
PTPN11
PTPN6
RANBP9
RIT2
RRAS
SH3BP5
SH3KBP1
SHC1
SIRPA
SNX18
SNX9
SPTAN1
TNIK
UBASH3A
ZAP70
74 interacting genes:
AKT1
ARHGAP32
BCAR3
BLK
BLNK
BTK
C1QBP
CRK
CRKL
EGFR
EPOR
ERBB2
FCGR2B
FES
FRS2
GAB2
GRAP2
GRB2
GTF2A1L
HCK
HSH2D
INPP5D
INPPL1
INSR
ITK
JAK1
LAT2
MAP3K3
MAPK1
MAPK3
MAPK4
MARK2
MET
MST1R
NCK1
NCK2
PDGFRB
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PTK6
PTPN11
PTPN18
RASA1
RET
SH2D1B
SH2D2A
SH2D3A
SHC1
SHC3
SLA
SLA2
SOCS3
SOCS6
SOS1
SRC
STAP1
SUPT6H
SYK
SYP
TEC
TNS1
TNS3
TNS4
TRIM15
VAV1
VAV2
VAV3
WEE2-AS1
YAP1
YES1
Entrez ID
6654
2549
HPRD ID
01681
05116
Ensembl ID
ENSG00000115904
ENSG00000109458
Uniprot IDs
G5E9C8
Q07889
B7Z3B9
Q13480
Q9HA84
PDB IDs
1AWE
1BKD
1DBH
1NVU
1NVV
1NVW
1NVX
1Q9C
1XD2
1XD4
1XDV
2II0
3KSY
4NYI
4NYJ
4NYM
4URU
4URV
4URW
4URX
4URY
4URZ
4US0
4US1
4US2
5OVD
5OVE
5OVF
5OVG
5OVH
5OVI
5WFO
5WFP
5WFQ
5WFR
6BVI
6BVJ
6BVK
6BVL
6BVM
6CUO
6CUP
6CUR
6D55
6D56
6D59
6D5E
6D5G
6D5H
6D5J
6D5L
6D5M
6D5V
6D5W
6EPL
6EPM
6EPN
6EPO
6EPP
6F08
6SCM
6SFR
6V94
6V9F
6V9J
6V9L
6V9M
6V9N
6V9O
6Y44
7AVI
7AVL
7AVS
7AVT
7AVU
7AVV
7KFZ
7UKR
7UKS
8BE2
8BE4
8BE5
8BE6
8BE7
8BE8
8BE9
8BEA
8XJJ
4QSY
Enriched GO Terms of Interacting Partners
?
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Enzyme-linked Receptor Protein Signaling Pathway
Intracellular Signal Transduction
Regulation Of Signal Transduction
Plasma Membrane
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Signaling
Intracellular Signaling Cassette
Peptidyl-tyrosine Phosphorylation
ERBB Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Cellular Component Organization
Antigen Receptor-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Positive Regulation Of MAPK Cascade
Cell Migration
Positive Regulation Of Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
Positive Regulation Of Cellular Component Organization
T Cell Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Immune System Process
Regulation Of Developmental Process
Cell Motility
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Signaling
Regulation Of Immune Response
Regulation Of Actin Filament-based Process
Response To Growth Factor
Cytosol
Receptor Tyrosine Kinase Binding
Schwann Cell Development
Cytoplasm
Regulation Of Cell Adhesion
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell Communication
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cytoskeleton Organization
Endocytosis
Regulation Of Anatomical Structure Morphogenesis
Cell Development
MAPK Cascade
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Intracellular Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Protein Tyrosine Kinase Activity
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
ERBB Signaling Pathway
Intracellular Signaling Cassette
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Immune Response
Protein Kinase Activity
Regulation Of Signal Transduction
Immune System Process
Antigen Receptor-mediated Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Kinase Activity
B Cell Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Fc Receptor Signaling Pathway
Cell Activation
Regulation Of MAPK Cascade
Non-membrane Spanning Protein Tyrosine Kinase Activity
Leukocyte Activation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Cytosol
Positive Regulation Of MAPK Cascade
Lymphocyte Activation
Protein Phosphorylation
Peptidyl-tyrosine Phosphorylation
Cell Migration
Phosphorylation
Insulin Receptor Signaling Pathway
Immune Effector Process
Fc-epsilon Receptor Signaling Pathway
Negative Regulation Of Immune System Process
Receptor Tyrosine Kinase Binding
Regulation Of Cell Adhesion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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