SOS1 and HRAS

  • Number of citations of the paper that reports this interaction (PMID 9690470)
  • 104
  • Data Source:
  • BioGRID (x-ray crystallography, x-ray crystallography)
  • HPRD (in vivo)

SOS1

HRAS

Gene Name son of sevenless homolog 1 (Drosophila) Harvey rat sarcoma viral oncogene homolog
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 52 interactors: ABI1 ABI3 ANXA2 ATP6V1E1 BIN1 CAV1 CD19 CD2AP CRK CRKL CSF1R EGFR EPS8 EPS8L1 EPS8L2 ERBB2 ERBB3 ESR1 FGFR1 FRS2 FYN GAB1 GRAP GRB2 HCK HDLBP HRAS ITSN1 ITSN2 LAT2 LCK MAPK1 MUC1 NCK1 NCK2 PACSIN1 PACSIN3 PIK3R2 PLCG1 PTPN11 PTPN6 RANBP9 RIT2 RRAS SH3BP5 SH3KBP1 SHC1 SNX18 SNX9 SPTAN1 TNIK ZAP70 78 interactors: AGTR1 ARAF ARHGEF1 BCL2 BRAF BRAP CAV1 CDC25A CDC25C DEAF1 DGKZ FNTA FNTB FYN GPSM2 GRB2 GRIN1 GRIN2D ICMT IKZF3 IL3 INSR IRAK1 IRAK2 ITSN1 KRT18 LGALS1 MAP2K1 MAPK8 MLLT4 NF1 PDE6D PDGFB PIK3CA PIK3CD PIK3CG PIK3R1 PLCE1 PRKCI PRKCZ RABAC1 RABGEF1 RAF1 RALA RALGDS RAP1B RAP1GDS1 RAPGEF1 RARRES3 RASA1 RASGRF1 RASGRP1 RASGRP4 RASIP1 RASSF1 RASSF2 RASSF5 RGL1 RGL2 RGL4 RGS12 RHOD RIN1 RIT2 RNF115 SHOC2 SNRPE SNX17 SOS1 SOS2 SRC TIAM1 TLR2 TLR9 TP73 TTC1 VAV1 ZBTB12
Entrez ID 6654 3265
HPRD ID 01681 01813
Ensembl ID ENSG00000115904 ENSG00000174775
Uniprot IDs G5E9C8 Q07889 P01112
PDB IDs 1AWE 1BKD 1DBH 1NVU 1NVV 1NVW 1NVX 1Q9C 1XD2 1XD4 1XDV 2II0 3KSY 121P 1AA9 1AGP 1BKD 1CLU 1CRP 1CRQ 1CRR 1CTQ 1GNP 1GNQ 1GNR 1HE8 1IAQ 1IOZ 1JAH 1JAI 1K8R 1LF0 1LF5 1LFD 1NVU 1NVV 1NVW 1NVX 1P2S 1P2T 1P2U 1P2V 1PLJ 1PLK 1PLL 1Q21 1QRA 1RVD 1WQ1 1XCM 1XD2 1XJ0 1ZVQ 1ZW6 221P 2C5L 2CE2 2CL0 2CL6 2CL7 2CLC 2CLD 2EVW 2GDP 2LCF 2LWI 2Q21 2QUZ 2RGA 2RGB 2RGC 2RGD 2RGE 2RGG 2UZI 2VH5 2X1V 3DDC 3I3S 3K8Y 3K9L 3K9N 3KKM 3KKN 3KUD 3L8Y 3L8Z 3LBH 3LBI 3LBN 3LO5 3OIU 3OIV 3OIW 3RRY 3RRZ 3RS0 3RS2 3RS3 3RS4 3RS5 3RS7 3RSL 3RSO 3TGP 421P 4DLR 4DLS 4DLT 4DLU 4DLV 4DLW 4DLX 4DLY 4DLZ 4DST 4DSU 4EFL 4EFM 4EFN 4G0N 4G3X 4K81 4Q21 521P 5P21 621P 6Q21 721P 821P
Enriched GO Terms of Interacting Partners?
Tagcloud ?
accordingly  antisense  b9  cascade  cascades  distal  gp130  il  independently  jak  lines  mapk  mediates  mediating  mitogen  mm  myeloma  next  occur  oligonucleotide  proliferated  proliferative  ras  regardless  sense  shc  stat1  stat3  triggered 
12th  arising  arose  carcinogenic  carrying  clustered  codon  contain  detectable  epithelium  find  fraction  gaa  gga  gland  indirectly  mammary  measure  methylurea  mutants  nitroso  nmu  organ  origin  preexisting  sectors  transition  untreated 
Tagcloud (Difference) ?
accordingly  antisense  b9  cascade  cascades  distal  gp130  il  independently  jak  lines  mapk  mediates  mediating  mitogen  mm  myeloma  next  occur  oligonucleotide  proliferated  proliferative  regardless  sense  shc  stat1  stat3  triggered 
12th  arising  arose  carcinogenic  carrying  clustered  codon  contain  detectable  epithelium  find  fraction  gaa  gga  gland  indirectly  mammary  measure  methylurea  mutants  nitroso  nmu  organ  origin  preexisting  sectors  transition  untreated 
Tagcloud (Intersection) ?
ras