SOS1 and RANBP9

Number of citations of the paper that reports this interaction (PMID 12147692)
33

Data Source:
HPRD (in vitro)

		SOS1	RANBP9
Gene Name		son of sevenless homolog 1 (Drosophila)	RAN binding protein 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Neuronal Cell Body	Nucleus Cytosol Microtubule Associated Complex
	Molecular Function	DNA Binding Ras Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Rho GTPase Activator Activity Protein Binding SH3 Domain Binding Protein Heterodimerization Activity	Protein Binding Ran GTPase Binding Enzyme Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Positive Regulation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Leukocyte Migration Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Protein Complex Assembly Microtubule Nucleation Axon Guidance
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade FCERI mediated MAPK activation Platelet Aggregation (Plug Formation) Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Regulation of KIT signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins SHC1 events in ERBB4 signaling Signalling to RAS Downstream signal transduction Signaling by Rho GTPases Signaling by FGFR mutants Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Signalling to ERKs Axon guidance IRS-mediated signalling IGF1R signaling cascade Rho GTPase cycle IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling Activation of Rac Downstream signaling of activated FGFR G alpha (12/13) signalling events NCAM signaling for neurite out-growth Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade Cell death signalling via NRAGE, NRIF and NADE SOS-mediated signalling SHC-mediated signalling Integrin alphaIIb beta3 signaling p75 NTR receptor-mediated signalling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins SHC-related events Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling Signal attenuation NRAGE signals death through JNK Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling FCERI mediated Ca+2 mobilization Constitutive Signaling by EGFRvIII Signaling by Robo receptor	Axon guidance L1CAM interactions
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		52 interactors: ABI1 ABI3 ANXA2 ATP6V1E1 BIN1 CAV1 CD19 CD2AP CRK CRKL CSF1R EGFR EPS8 EPS8L1 EPS8L2 ERBB2 ERBB3 ESR1 FGFR1 FRS2 FYN GAB1 GRAP GRB2 HCK HDLBP HRAS ITSN1 ITSN2 LAT2 LCK MAPK1 MUC1 NCK1 NCK2 PACSIN1 PACSIN3 PIK3R2 PLCG1 PTPN11 PTPN6 RANBP9 RIT2 RRAS SH3BP5 SH3KBP1 SHC1 SNX18 SNX9 SPTAN1 TNIK ZAP70	51 interactors: ADAP1 ADAP2 APC AR AXL BACE1 BRCA1 CACNA1G CALB1 CBS CDK11B CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 FMR1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM MAPK6 MET MKLN1 MPHOSPH8 NCOA6 NCOR2 OPRM1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOS1 SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1
Entrez ID		6654	10048
HPRD ID		01681	04835
Ensembl ID		ENSG00000115904	ENSG00000010017
Uniprot IDs		G5E9C8 Q07889	Q96S59
PDB IDs		1AWE 1BKD 1DBH 1NVU 1NVV 1NVW 1NVX 1Q9C 1XD2 1XD4 1XDV 2II0 3KSY
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Fc Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Response To Fibroblast Growth Factor Innate Immune Response Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Protein Kinase Activity Locomotion Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Response To Growth Factor Immune System Process Regulation Of Signaling Regulation Of Immune System Process Phosphatidylinositol-mediated Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Immune Response Leukocyte Migration Positive Regulation Of Protein Modification Process Endocytosis Positive Regulation Of Protein Kinase Activity Defense Response Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Metabolic Process	Multicellular Organismal Development Anatomical Structure Development Developmental Process System Development Organ Development Response To Organic Substance Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Cell Communication Cellular Response To Organic Substance Signal Transduction Cellular Response To Organic Cyclic Compound Signaling DNA-templated Transcription, Initiation Cellular Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Response To Stimulus Response To Organic Cyclic Compound Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Tissue Development Response To Lipid Nervous System Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cellular Process Steroid Hormone Mediated Signaling Pathway Response To Growth Factor Epithelium Development Wound Healing Negative Regulation Of Signal Transduction Regulation Of Cell Proliferation Response To Hormone Reproductive Process Regulation Of Intracellular Signal Transduction Apoptotic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Hormone-mediated Signaling Pathway Cell Activation Negative Regulation Of Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Tagcloud ?		accordingly antisense b9 cascade cascades distal gp130 il independently jak lines mapk mediates mediating mitogen mm myeloma next occur oligonucleotide proliferated proliferative ras regardless sense shc stat1 stat3 triggered	accelerates apdeltae9 brains cortex cortical deficits dendritic density egfp exacerbated hippocampus immunoreactive learning mushroom plaque puncta reductions skills spine spines spinophilin striking synapses thin traces transgenic triple vulnerable wt
Tagcloud (Difference) ?		accordingly antisense b9 cascade cascades distal gp130 il independently jak lines mapk mediates mediating mitogen mm myeloma next occur oligonucleotide proliferated proliferative ras regardless sense shc stat1 stat3 triggered	accelerates apdeltae9 brains cortex cortical deficits dendritic density egfp exacerbated hippocampus immunoreactive learning mushroom plaque puncta reductions skills spine spines spinophilin striking synapses thin traces transgenic triple vulnerable wt
Tagcloud (Intersection) ?