SOS1 and LAT2

Number of citations of the paper that reports this interaction (PMID 12486104)
48

Data Source:
HPRD (in vitro)

		SOS1	LAT2
Gene Name		son of sevenless homolog 1 (Drosophila)	linker for activation of T cells family, member 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Neuronal Cell Body	Plasma Membrane Integral Component Of Membrane Mast Cell Granule Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Ras Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Rho GTPase Activator Activity Protein Binding SH3 Domain Binding Protein Heterodimerization Activity	Protein Binding SH2 Domain Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Positive Regulation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Leukocyte Migration Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Mast Cell Degranulation Innate Immune Response B Cell Receptor Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade FCERI mediated MAPK activation Platelet Aggregation (Plug Formation) Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Regulation of KIT signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins SHC1 events in ERBB4 signaling Signalling to RAS Downstream signal transduction Signaling by Rho GTPases Signaling by FGFR mutants Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Signalling to ERKs Axon guidance IRS-mediated signalling IGF1R signaling cascade Rho GTPase cycle IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling Activation of Rac Downstream signaling of activated FGFR G alpha (12/13) signalling events NCAM signaling for neurite out-growth Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade Cell death signalling via NRAGE, NRIF and NADE SOS-mediated signalling SHC-mediated signalling Integrin alphaIIb beta3 signaling p75 NTR receptor-mediated signalling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins SHC-related events Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling Signal attenuation NRAGE signals death through JNK Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling FCERI mediated Ca+2 mobilization Constitutive Signaling by EGFRvIII Signaling by Robo receptor	Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		52 interactors: ABI1 ABI3 ANXA2 ATP6V1E1 BIN1 CAV1 CD19 CD2AP CRK CRKL CSF1R EGFR EPS8 EPS8L1 EPS8L2 ERBB2 ERBB3 ESR1 FGFR1 FRS2 FYN GAB1 GRAP GRB2 HCK HDLBP HRAS ITSN1 ITSN2 LAT2 LCK MAPK1 MUC1 NCK1 NCK2 PACSIN1 PACSIN3 PIK3R2 PLCG1 PTPN11 PTPN6 RANBP9 RIT2 RRAS SH3BP5 SH3KBP1 SHC1 SNX18 SNX9 SPTAN1 TNIK ZAP70	7 interactors: CBL GAB1 GRB2 PLCG1 PLCG2 SOS1 UBQLN4
Entrez ID		6654	7462
HPRD ID		01681	09304
Ensembl ID		ENSG00000115904	ENSG00000086730
Uniprot IDs		G5E9C8 Q07889	Q9GZY6
PDB IDs		1AWE 1BKD 1DBH 1NVU 1NVV 1NVW 1NVX 1Q9C 1XD2 1XD4 1XDV 2II0 3KSY	3MAZ
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Fc Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Response To Fibroblast Growth Factor Innate Immune Response Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Protein Kinase Activity Locomotion Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Response To Growth Factor Immune System Process Regulation Of Signaling Regulation Of Immune System Process Phosphatidylinositol-mediated Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Immune Response Leukocyte Migration Positive Regulation Of Protein Modification Process Endocytosis Positive Regulation Of Protein Kinase Activity Defense Response Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Metabolic Process	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Response To Organic Substance Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Defense Response Regulation Of Body Fluid Levels Wound Healing Platelet Activation Cellular Response To Insulin Stimulus Response To Wounding Phospholipid Catabolic Process Leukocyte Migration Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phagocytosis Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Insulin Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Response To Peptide Inositol Phosphate Metabolic Process
Tagcloud ?		accordingly antisense b9 cascade cascades distal gp130 il independently jak lines mapk mediates mediating mitogen mm myeloma next occur oligonucleotide proliferated proliferative ras regardless sense shc stat1 stat3 triggered	adaptor allergic balance cascade collectively degranulation dysregulated effectors fcepsilonri gamma1 grb2 hyper ige ko lat1 linker linking mast negatively orchestrates plc proinflammatory reactions responsiveness signalosome slp tespa1 triggers tuning
Tagcloud (Difference) ?		accordingly antisense b9 cascades distal gp130 il independently jak lines mapk mediates mediating mitogen mm myeloma next occur oligonucleotide proliferated proliferative ras regardless sense shc stat1 stat3 triggered	adaptor allergic balance collectively degranulation dysregulated effectors fcepsilonri gamma1 grb2 hyper ige ko lat1 linker linking mast negatively orchestrates plc proinflammatory reactions responsiveness signalosome slp tespa1 triggers tuning
Tagcloud (Intersection) ?		cascade