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UBOX5 and MLH1
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
UBOX5
MLH1
Gene Name
U-box domain containing 5
mutL homolog 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nuclear Body
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chiasma
Membrane
MutLalpha Complex
Molecular Function
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Single-stranded DNA Binding
Protein Binding
ATP Binding
ATPase Activity
Guanine/thymine Mispair Binding
MutSalpha Complex Binding
Biological Process
Protein Polyubiquitination
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Resolution Of Meiotic Recombination Intermediates
DNA Repair
Mismatch Repair
Double-strand Break Repair Via Nonhomologous End Joining
Male Meiosis Chromosome Segregation
Synapsis
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Somatic Hypermutation Of Immunoglobulin Genes
Meiotic Metaphase I Plate Congression
Isotype Switching
Negative Regulation Of Mitotic Recombination
Oogenesis
Meiotic Spindle Midzone Assembly
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Meiotic recombination
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions
19 interactors:
MLH1
NEDD4
TRAF6
TRAIP
TRIM23
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2K
UBE2L3
UBE2V1
UBE2W
USP2
VCP
74 interactors:
ABCC3
ABHD16A
ACER3
ACTG2
AGR2
AIFM1
ALDOA
ANXA6
AP2B1
APRT
ARAF
ASS1
ATF2
BLM
BRCA1
CAB39L
CAPN5
CASP3
CKAP4
CKB
CXorf57
DDX47
EEF1G
EEF2
EIF2A
ELP6
EXO1
EXOC3
FBXO32
FCGBP
FLNB
FRMD6
GABARAP
GSTP1
IGKC
KPNA2
LGALS4
MAP2K6
MBD4
MLH3
MSH3
MSH4
MUC2
MYC
MYL6
MYOG
NDRG1
NT5C3B
ORC4
PARP12
PARVA
PCNA
PMS1
PMS2
PSMA1
PTGDS
PTPRH
RAD23B
RAD9A
RAPGEFL1
SEC61A1
SELENBP1
SERPINF1
SPERT
SQSTM1
STAP2
TRIM23
TRIM29
TXN
TXN2
UBOX5
VAMP8
ZC3H11A
ZER1
Entrez ID
22888
4292
HPRD ID
15605
00390
Ensembl ID
ENSG00000185019
ENSG00000076242
Uniprot IDs
O94941
P40692
Q59EG3
PDB IDs
3NA3
3RBN
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein K63-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Protein Catabolic Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Catabolic Process
Cellular Response To Stress
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor Signaling Pathway
Protein Monoubiquitination
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Cellular Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Innate Immune Response
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Regulation Of Innate Immune Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Stimulus
ISG15-protein Conjugation
Response To Stimulus
Response To Stress
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Catabolic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Metabolic Process
Cellular Response To DNA Damage Stimulus
Cellular Response To Stress
Cellular Response To DNA Damage Stimulus
Cellular Response To Stimulus
Response To Stimulus
Mismatch Repair
Response To Stress
DNA Metabolic Process
DNA Catabolic Process
DNA Recombination
Negative Regulation Of Cell Cycle
DNA Repair
Cell Cycle
Cell Cycle Process
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Response To Organic Substance
DNA Damage Checkpoint
Mitotic DNA Damage Checkpoint
Mucus Secretion
Regulation Of Cell Cycle
Mitotic DNA Integrity Checkpoint
Nitrogen Compound Metabolic Process
Cellular Response To Organic Substance
Apoptotic Process
Programmed Cell Death
Nucleic Acid Phosphodiester Bond Hydrolysis
Cell Death
Death
Response To Abiotic Stimulus
Cell Cycle Checkpoint
Apoptotic Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Cellular Response To Dexamethasone Stimulus
Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Response To Dexamethasone
Homeostatic Process
Mitotic Cell Cycle Checkpoint
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Catabolic Process, Exonucleolytic
Somatic Recombination Of Immunoglobulin Gene Segments
G2 DNA Damage Checkpoint
DNA Catabolic Process, Endonucleolytic
Regulation Of Apoptotic DNA Fragmentation
Somatic Diversification Of Immunoglobulins
Reciprocal Meiotic Recombination
Anatomical Structure Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Actin-mediated Cell Contraction
Tagcloud
?
9p24
actionable
arid1a
atlas
barr
bystander
cd274
cdkn2a
classifier
comes
comprises
cpg
ebv
enrollment
epstein
fail
gastrogenus
genomically
harbor
innocent
instability
intimately
l2
lytic
microsatellite
msi
noncoding
pdcd1lg2
qualify
Tagcloud (Difference)
?
9p24
actionable
arid1a
atlas
barr
bystander
cd274
cdkn2a
classifier
comes
comprises
cpg
ebv
enrollment
epstein
fail
gastrogenus
genomically
harbor
innocent
instability
intimately
l2
lytic
microsatellite
msi
noncoding
pdcd1lg2
qualify
Tagcloud (Intersection)
?