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UBOX5 and UBE2K
Number of citations of the paper that reports this interaction (PMID
19549727
)
40
Data Source:
BioGRID
(two hybrid)
UBOX5
UBE2K
Gene Name
U-box domain containing 5
ubiquitin-conjugating enzyme E2K
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nuclear Body
Nucleus
Cytoplasm
Actin Cytoskeleton
Intermediate Filament Cytoskeleton
Extracellular Vesicular Exosome
Molecular Function
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Protein Ligase Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Protein K48-linked Ubiquitination
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Antigen processing: Ubiquitination & Proteasome degradation
Negative regulators of RIG-I/MDA5 signaling
Class I MHC mediated antigen processing & presentation
Innate Immune System
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
19 interactors:
MLH1
NEDD4
TRAF6
TRAIP
TRIM23
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2K
UBE2L3
UBE2V1
UBE2W
USP2
VCP
68 interactors:
AMFR
ANAPC11
BFAR
BIRC7
BIRC8
BRCA1
CASP12
CBLC
CDC6
DDI1
DDX58
DIABLO
DTX3
DTX3L
DZIP3
FZR1
HTT
ITCH
ITSN1
LRSAM1
MARCH3
MARCH7
MDM2
MID1
MIPOL1
MKRN2
MKRN3
NEDD4L
NEDD8
NFKB1
NUB1
PIAS4
PRPF40A
PRRG4
RBCK1
REL
RING1
RNF111
RNF114
RNF125
RNF138
RNF144A
RNF167
RNF2
RNF32
RNF4
RNF41
RNF5
SIAH1
TP53
TRAF7
TRAIP
TRIM2
TRIM27
TRIM3
TRIM31
TRIM34
TRIM35
TRIM39
TRIM43
TRIM5
UBA1
UBC
UBE2I
UBOX5
UHRF2
WWP2
ZDHHC17
Entrez ID
22888
3093
HPRD ID
15605
04165
Ensembl ID
ENSG00000185019
ENSG00000078140
Uniprot IDs
O94941
B4DIZ2
P61086
PDB IDs
1YLA
2O25
3E46
3F92
3K9O
3K9P
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein K63-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Protein Catabolic Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Catabolic Process
Cellular Response To Stress
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor Signaling Pathway
Protein Monoubiquitination
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Cellular Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Innate Immune Response
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Regulation Of Innate Immune Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Stimulus
ISG15-protein Conjugation
Response To Stimulus
Response To Stress
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Catabolic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Metabolic Process
Cellular Response To DNA Damage Stimulus
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Cellular Protein Modification Process
Protein Polyubiquitination
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Cellular Metabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Proteolysis
Proteasomal Protein Catabolic Process
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cell Death
Protein K63-linked Ubiquitination
Negative Regulation Of Cellular Metabolic Process
Metabolic Process
Regulation Of Apoptotic Process
Catabolic Process
Protein Autoubiquitination
Positive Regulation Of Signal Transduction
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of RNA Biosynthetic Process
Viral Process
Neuron Apoptotic Process
Response To Stress
Negative Regulation Of Biosynthetic Process
Regulation Of Viral Release From Host Cell
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Process
Neuron Death
Regulation Of Signaling
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cell Cycle
Tagcloud
?
antiviral
attributes
breadth
chains
conjugase
cooperated
demands
e3
elicits
elusive
epsilon
hundreds
identifies
ifn
ikkepsilon
interacted
interferons
isg
isgs
k48
ligase
polyubiquitin
stat1
trim
trim6
tripartite
ubiquitin
unanchored
unrecognized
Tagcloud (Difference)
?
antiviral
attributes
breadth
chains
conjugase
cooperated
demands
e3
elicits
elusive
epsilon
hundreds
identifies
ifn
ikkepsilon
interacted
interferons
isg
isgs
k48
ligase
polyubiquitin
stat1
trim
trim6
tripartite
ubiquitin
unanchored
unrecognized
Tagcloud (Intersection)
?