MTF2 and PRMT6

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		MTF2	PRMT6
Gene Name		metal response element binding transcription factor 2	protein arginine methyltransferase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm ESC/E(Z) Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Zinc Ion Binding Methylated Histone Binding	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Segment Specification Gene Expression Chromatin Modification Stem Cell Maintenance Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Differentiation Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated
Pathways		Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS			Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		10 interactors: CREB1 GPRASP1 GSK3B KDM1A PRKD2 PRMT6 SMAD3 SUV39H1 SUV39H2 TMED9	91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		22823	55170
HPRD ID		14342	10505
Ensembl ID		ENSG00000143033	ENSG00000198890
Uniprot IDs		B4DZ69 B4DZG1 Q7Z534 Q96G26 Q9Y483	Q96LA8
PDB IDs			4HC4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Histone H3-K9 Dimethylation Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Rhythmic Process Histone H3-K9 Trimethylation Peptidyl-lysine Dimethylation Histone Modification Positive Regulation Of Organelle Organization Histone Methylation Regulation Of Organelle Organization Peptidyl-amino Acid Modification Negative Regulation Of Circadian Rhythm Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Methylation Regulation Of RNA Metabolic Process Peptidyl-lysine Trimethylation Viral Process Cellular Response To Growth Factor Stimulus Cellular Protein Modification Process Response To Growth Factor Chromatin Modification Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Regulation Of Immune System Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Response To Stress Transcription, DNA-templated Regulation Of Binding Chromatin Organization RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell-matrix Adhesion Cellular Response To Stress Positive Regulation Of Gene Expression Response To Hypoxia Pituitary Gland Development Positive Regulation Of Stem Cell Differentiation Protein Metabolic Process	Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation
Tagcloud ?		aebp2 biotap c10orf12 c17orf96 cbx4 connecting disrupt eed ehmt1 exclusive fail interactors iterative jarid2 mutually phf1 prc1 prc2 preservation pulldowns reciprocal repressive seq suz12 tagged unexpected validate validating xl	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Difference) ?		aebp2 biotap c10orf12 c17orf96 cbx4 connecting disrupt eed ehmt1 exclusive fail interactors iterative jarid2 mutually phf1 prc1 prc2 preservation pulldowns reciprocal repressive seq suz12 tagged unexpected validate validating xl	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Intersection) ?