MTF2 and PRKD2

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)

		MTF2	PRKD2
Gene Name		metal response element binding transcription factor 2	protein kinase D2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm ESC/E(Z) Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane
	Molecular Function	DNA Binding Zinc Ion Binding Methylated Histone Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Segment Specification Gene Expression Chromatin Modification Stem Cell Maintenance Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Differentiation Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Cell Adhesion Cell Death Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Endothelial Tube Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS			Chronic lymphocytic leukemia ( 18758461)
Protein-Protein Interactions		10 interactors: CREB1 GPRASP1 GSK3B KDM1A PRKD2 PRMT6 SMAD3 SUV39H1 SUV39H2 TMED9	17 interactors: CASK DST GLRX3 GORASP1 GRIP1 HDAC7 HEY1 IFNAR1 MTF2 PDLIM7 PFDN1 PSG3 RARB RRBP1 RXRA SNRNP70 TGOLN2
Entrez ID		22823	25865
HPRD ID		14342	09523
Ensembl ID		ENSG00000143033	ENSG00000105287
Uniprot IDs		B4DZ69 B4DZG1 Q7Z534 Q96G26 Q9Y483	M0QZW1 M0R2R2 Q8NCK8 Q9BZL6
PDB IDs			2COA 3BGM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Histone H3-K9 Dimethylation Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Rhythmic Process Histone H3-K9 Trimethylation Peptidyl-lysine Dimethylation Histone Modification Positive Regulation Of Organelle Organization Histone Methylation Regulation Of Organelle Organization Peptidyl-amino Acid Modification Negative Regulation Of Circadian Rhythm Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Methylation Regulation Of RNA Metabolic Process Peptidyl-lysine Trimethylation Viral Process Cellular Response To Growth Factor Stimulus Cellular Protein Modification Process Response To Growth Factor Chromatin Modification Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Regulation Of Immune System Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Response To Stress Transcription, DNA-templated Regulation Of Binding Chromatin Organization RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell-matrix Adhesion Cellular Response To Stress Positive Regulation Of Gene Expression Response To Hypoxia Pituitary Gland Development Positive Regulation Of Stem Cell Differentiation Protein Metabolic Process	Positive Regulation Of Gene Expression Regulation Of Osteoblast Differentiation Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Chamber Development Developmental Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Cellular Response To Steroid Hormone Stimulus Multicellular Organismal Development Cardiac Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Intracellular Receptor Signaling Pathway Heart Development Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heart Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Glandular Epithelial Cell Differentiation Cellular Response To Hormone Stimulus Negative Regulation Of Transcription, DNA-templated Ventricular Cardiac Muscle Tissue Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Ossification Regulation Of RNA Metabolic Process Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Positive Regulation Of Osteoblast Differentiation Striated Muscle Tissue Development Negative Regulation Of Cell Differentiation Muscle Cell Differentiation Negative Regulation Of Gene Expression Muscle Tissue Development Negative Regulation Of Biosynthetic Process Positive Regulation Of Translational Initiation By Iron Cardiac Septum Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Vasculogenesis Positive Regulation Of Ossification
Tagcloud ?		aebp2 biotap c10orf12 c17orf96 cbx4 connecting disrupt eed ehmt1 exclusive fail interactors iterative jarid2 mutually phf1 prc1 prc2 preservation pulldowns reciprocal repressive seq suz12 tagged unexpected validate validating xl	a172 cdk2 crt0066101 dismal e2f1 gbm gbm2 gli25 glioblastoma glioma gliomagenesis gm133 hallmarks hypophosphorylation mer multiforme mut p15 pkb pkc prb profoundly retinoblastoma senescence silencing t98g u251 u87mg
Tagcloud (Difference) ?		aebp2 biotap c10orf12 c17orf96 cbx4 connecting disrupt eed ehmt1 exclusive fail interactors iterative jarid2 mutually phf1 prc1 prc2 preservation pulldowns reciprocal repressive seq suz12 tagged unexpected validate validating xl	a172 cdk2 crt0066101 dismal e2f1 gbm gbm2 gli25 glioblastoma glioma gliomagenesis gm133 hallmarks hypophosphorylation mer multiforme mut p15 pkb pkc prb profoundly retinoblastoma senescence silencing t98g u251 u87mg
Tagcloud (Intersection) ?