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FDX1 and PRKAB2
Number of citations of the paper that reports this interaction (PMID
19616115
)
4
Data Source:
BioGRID
(two hybrid)
FDX1
PRKAB2
Gene Name
ferredoxin 1
protein kinase, AMP-activated, beta 2 non-catalytic subunit
Image
Gene Ontology Annotations
Cellular Component
Mitochondrion
Mitochondrial Matrix
Nucleoplasm
Cytosol
AMP-activated Protein Kinase Complex
Molecular Function
Iron Ion Binding
Electron Carrier Activity
2 Iron, 2 Sulfur Cluster Binding
AMP-activated Protein Kinase Activity
Protein Binding
Identical Protein Binding
Biological Process
C21-steroid Hormone Biosynthetic Process
Xenobiotic Metabolic Process
Steroid Metabolic Process
Cholesterol Metabolic Process
Sterol Metabolic Process
Hormone Biosynthetic Process
Small Molecule Metabolic Process
Oxidation-reduction Process
Energy Reserve Metabolic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Fatty Acid Biosynthetic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Regulation Of Protein Kinase Activity
Membrane Organization
Pathways
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Metabolism of lipids and lipoproteins
Pregnenolone biosynthesis
Mitochondrial iron-sulfur cluster biogenesis
Metabolic disorders of biological oxidation enzymes
Phase 1 - Functionalization of compounds
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Electron transport from NADPH to Ferredoxin
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
Endogenous sterols
Biological oxidations
Defective FMO3 causes Trimethylaminuria (TMAU)
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Defective CYP1B1 causes Glaucoma
Metabolism of steroid hormones and vitamin D
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Drugs
Mitotane
Adenosine monophosphate
Diseases
GWAS
Protein-Protein Interactions
5 interactors:
CYCS
CYP11A1
CYP11B2
FDXR
PRKAB2
70 interactors:
ADAMTSL4
BANP
BEND5
BLZF1
CALCOCO2
CASP6
CCDC33
CCDC36
CDX4
CREB3L1
CRX
CSNK2B
DAO
DDIT4L
DICER1
DST
EPM2A
FAM208B
FDX1
FLNC
GATA1
GATAD2B
GET4
GNB2L1
GOLGA2
GRN
IKZF1
IKZF3
KCTD5
KLF15
KRT40
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP9-2
KRTAP9-4
LZTS2
MAGED1
MDFI
MEOX2
NEBL
PIAS2
PRDM14
PRKAA1
PRKAA2
PRKAG1
PRKAG2
PRKAG3
PSME3
PYGM
RBPMS
REL
RHEBL1
RIMBP3
SPRY2
STX11
STX19
TADA2A
TCF4
TP53BP2
TRAF2
TRIM10
UBXN11
YY1AP1
ZBTB32
Entrez ID
2230
5565
HPRD ID
00059
04117
Ensembl ID
ENSG00000137714
ENSG00000131791
Uniprot IDs
P10109
O43741
PDB IDs
3N9Y
3N9Z
3NA0
3NA1
3P1M
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2Y94
2YA3
4EAI
4EAJ
Enriched GO Terms of Interacting Partners
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C21-steroid Hormone Biosynthetic Process
C21-steroid Hormone Metabolic Process
Hormone Biosynthetic Process
Cellular Ketone Metabolic Process
Steroid Biosynthetic Process
Oxidation-reduction Process
Lipid Biosynthetic Process
Sterol Metabolic Process
Xenobiotic Metabolic Process
Cellular Response To Xenobiotic Stimulus
Response To Xenobiotic Stimulus
Hormone Metabolic Process
Small Molecule Metabolic Process
Steroid Metabolic Process
Regulation Of Hormone Levels
Alcohol Metabolic Process
Lipid Metabolic Process
Generation Of Precursor Metabolites And Energy
Cellular Response To Hormone Stimulus
Cholesterol Metabolic Process
Cellular Response To Metal Ion
Cellular Response To Inorganic Substance
Response To Genistein
Regulation Of Blood Volume By Renal Aldosterone
Response To Hormone
Granulosa Cell Differentiation
Aldosterone Biosynthetic Process
Cortisol Biosynthetic Process
Fractalkine Metabolic Process
Response To Reactive Oxygen Species
Mitochondrial Electron Transport, Cytochrome C To Oxygen
Response To Fungicide
Chemokine Metabolic Process
Testosterone Biosynthetic Process
Response To Hydroxyisoflavone
Mineralocorticoid Biosynthetic Process
Cellular Response To Potassium Ion
Phthalate Metabolic Process
Dibenzo-p-dioxin Metabolic Process
Energy Derivation By Oxidation Of Organic Compounds
Cellular Response To Peptide Hormone Stimulus
Biphenyl Metabolic Process
Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
Carnitine Shuttle
Cellular Response To Stimulus
Cellular Response To Peptide
Response To Metal Ion
Response To Potassium Ion
Glucocorticoid Biosynthetic Process
Response To L-ascorbic Acid
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle Arrest
Transcription, DNA-templated
Regulation Of Gene Expression
RNA Biosynthetic Process
Glycogen Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cell Cycle
Energy Reserve Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Polysaccharide Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Organelle Organization
Gene Expression
Cell Cycle Process
Positive Regulation Of Phosphorylation
RNA Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Signaling
Fatty Acid Biosynthetic Process
Cellular Process
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Binding
Regulation Of Metabolic Process
Regulation Of Carbohydrate Metabolic Process
Regulation Of Phosphorylation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Cell Death
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Tagcloud (Intersection)
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