FDX1 and FDXR

Number of citations of the paper that reports this interaction (PMID 1917982)
18

Data Source:
HPRD (in vitro)

		FDX1	FDXR
Gene Name		ferredoxin 1	ferredoxin reductase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix
	Molecular Function	Iron Ion Binding Electron Carrier Activity 2 Iron, 2 Sulfur Cluster Binding	Ferredoxin-NADP+ Reductase Activity Protein Binding NADPH-adrenodoxin Reductase Activity
	Biological Process	C21-steroid Hormone Biosynthetic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Hormone Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process	Generation Of Precursor Metabolites And Energy Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Ubiquinone Biosynthetic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Mitochondrial iron-sulfur cluster biogenesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Electron transport from NADPH to Ferredoxin Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Mitochondrial iron-sulfur cluster biogenesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Electron transport from NADPH to Ferredoxin Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs		Mitotane
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CYCS CYP11A1 CYP11B2 FDXR PRKAB2	3 interactors: FDX1 FHIT POU2F1
Entrez ID		2230	2232
HPRD ID		00059	00060
Ensembl ID		ENSG00000137714	ENSG00000161513
Uniprot IDs		P10109	P22570 Q6GSK2
PDB IDs		3N9Y 3N9Z 3NA0 3NA1 3P1M
Enriched GO Terms of Interacting Partners?		C21-steroid Hormone Biosynthetic Process C21-steroid Hormone Metabolic Process Hormone Biosynthetic Process Cellular Ketone Metabolic Process Steroid Biosynthetic Process Oxidation-reduction Process Lipid Biosynthetic Process Sterol Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Hormone Metabolic Process Small Molecule Metabolic Process Steroid Metabolic Process Regulation Of Hormone Levels Alcohol Metabolic Process Lipid Metabolic Process Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Cholesterol Metabolic Process Cellular Response To Metal Ion Cellular Response To Inorganic Substance Response To Genistein Regulation Of Blood Volume By Renal Aldosterone Response To Hormone Granulosa Cell Differentiation Aldosterone Biosynthetic Process Cortisol Biosynthetic Process Fractalkine Metabolic Process Response To Reactive Oxygen Species Mitochondrial Electron Transport, Cytochrome C To Oxygen Response To Fungicide Chemokine Metabolic Process Testosterone Biosynthetic Process Response To Hydroxyisoflavone Mineralocorticoid Biosynthetic Process Cellular Response To Potassium Ion Phthalate Metabolic Process Dibenzo-p-dioxin Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Biphenyl Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Carnitine Shuttle Cellular Response To Stimulus Cellular Response To Peptide Response To Metal Ion Response To Potassium Ion Glucocorticoid Biosynthetic Process Response To L-ascorbic Acid	Olfactory Placode Formation Lens Induction In Camera-type Eye
Tagcloud ?			biomarker ccng1 cis constructed curves ddb2 documented dose doses estimate evident fit fulfill gy individual inter ionizing irradiated linear mgy polynomial proportionality ranges reproducibility requirements responsive transcriptionally variability variation
Tagcloud (Difference) ?			biomarker ccng1 cis constructed curves ddb2 documented dose doses estimate evident fit fulfill gy individual inter ionizing irradiated linear mgy polynomial proportionality ranges reproducibility requirements responsive transcriptionally variability variation
Tagcloud (Intersection) ?