FDX1 and CYCS

Number of citations of the paper that reports this interaction (PMID 6270113)
3

Data Source:
HPRD (in vivo)

		FDX1	CYCS
Gene Name		ferredoxin 1	cytochrome c, somatic
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respiratory Chain
	Molecular Function	Iron Ion Binding Electron Carrier Activity 2 Iron, 2 Sulfur Cluster Binding	Protein Serine/threonine Phosphatase Activity Iron Ion Binding Protein Binding Heme Binding Electron Transporter, Transferring Electrons From CoQH2-cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity
	Biological Process	C21-steroid Hormone Biosynthetic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Hormone Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process	Response To Reactive Oxygen Species Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic DNA Fragmentation Apoptotic Process Organelle Organization Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Dephosphorylation Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Cellular Respiration Transmembrane Transport Intrinsic Apoptotic Signaling Pathway
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Mitochondrial iron-sulfur cluster biogenesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Electron transport from NADPH to Ferredoxin Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Organelle biogenesis and maintenance Detoxification of Reactive Oxygen Species Respiratory electron transport Cytochrome c-mediated apoptotic response Mitochondrial biogenesis Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome Release of apoptotic factors from the mitochondria Apoptotic factor-mediated response Programmed Cell Death Transcriptional activation of mitochondrial biogenesis The citric acid (TCA) cycle and respiratory electron transport Orphan transporters Intrinsic Pathway for Apoptosis
Drugs		Mitotane	Minocycline Protoporphyrin Ix Containing Co Heme Heme C Protoporphyrin Ix Containing Zn N-Trimethyllysine Zinc Substituted Heme C
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		5 interactors: CYCS CYP11A1 CYP11B2 FDXR PRKAB2	20 interactors: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2
Entrez ID		2230	54205
HPRD ID		00059	00479
Ensembl ID		ENSG00000137714
Uniprot IDs		P10109	G4XXL9 P99999
PDB IDs		3N9Y 3N9Z 3NA0 3NA1 3P1M	1J3S 3NWV
Enriched GO Terms of Interacting Partners?		C21-steroid Hormone Biosynthetic Process C21-steroid Hormone Metabolic Process Hormone Biosynthetic Process Cellular Ketone Metabolic Process Steroid Biosynthetic Process Oxidation-reduction Process Lipid Biosynthetic Process Sterol Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Hormone Metabolic Process Small Molecule Metabolic Process Steroid Metabolic Process Regulation Of Hormone Levels Alcohol Metabolic Process Lipid Metabolic Process Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Cholesterol Metabolic Process Cellular Response To Metal Ion Cellular Response To Inorganic Substance Response To Genistein Regulation Of Blood Volume By Renal Aldosterone Response To Hormone Granulosa Cell Differentiation Aldosterone Biosynthetic Process Cortisol Biosynthetic Process Fractalkine Metabolic Process Response To Reactive Oxygen Species Mitochondrial Electron Transport, Cytochrome C To Oxygen Response To Fungicide Chemokine Metabolic Process Testosterone Biosynthetic Process Response To Hydroxyisoflavone Mineralocorticoid Biosynthetic Process Cellular Response To Potassium Ion Phthalate Metabolic Process Dibenzo-p-dioxin Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Biphenyl Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Carnitine Shuttle Cellular Response To Stimulus Cellular Response To Peptide Response To Metal Ion Response To Potassium Ion Glucocorticoid Biosynthetic Process Response To L-ascorbic Acid	Intrinsic Apoptotic Signaling Pathway Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Alkaloid Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Cellular Respiration Cell Death Death Neuron Apoptotic Process Regulation Of Cell Death Mitochondrial Membrane Organization Response To Biotic Stimulus Neuron Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway L-ascorbic Acid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Anoikis Regulation Of Neuron Death Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Energy Derivation By Oxidation Of Organic Compounds Zymogen Activation Programmed Cell Death Respiratory Electron Transport Chain Positive Regulation Of Cell Death Regulation Of Anoikis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Steroid Biosynthetic Process Response To Metal Ion Positive Regulation Of Cysteine-type Endopeptidase Activity Electron Transport Chain Sterol Metabolic Process Positive Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Execution Phase Of Apoptosis Response To Other Organism Positive Regulation Of Peptidase Activity Mitochondrion Organization Small Molecule Metabolic Process
Tagcloud ?			alternate apical apoptosome apoptotic atg5 atg7 autophagic autophagosome autophagy bak1 casp8 casp9 caspase caspases chemoresistance coincides cytochrome defective devoid existence facilitating fadd highlighting impacted normally platform problem revealing tackling
Tagcloud (Difference) ?			alternate apical apoptosome apoptotic atg5 atg7 autophagic autophagosome autophagy bak1 casp8 casp9 caspase caspases chemoresistance coincides cytochrome defective devoid existence facilitating fadd highlighting impacted normally platform problem revealing tackling
Tagcloud (Intersection) ?