FDX1 and CYP11B2

Number of citations of the paper that reports this interaction (PubMedID 3872685)
0

Data Source:
HPRD (in vitro)

		FDX1	CYP11B2
Description		ferredoxin 1	cytochrome P450 family 11 subfamily B member 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Iron Ion Binding Electron Transfer Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding	Monooxygenase Activity Steroid 11-beta-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding Corticosterone 18-monooxygenase Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Cellular Response To CAMP P450-containing Electron Transport Chain Cellular Response To Forskolin	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Potassium Ion Homeostasis Sodium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus
Pathways		Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR Protein lipoylation	Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B2 causes CMO-1 deficiency
Drugs		Mitotane	Spironolactone Levoketoconazole Osilodrostat
Diseases			Aldosterone synthase deficiency; Corticosterone methyloxidase type I deficiency; Corticosterone methyloxidase type II deficiency Glucocorticoid-remediable aldosteronism (GRA)
GWAS		Cognitive function ( 24684796) Coronary artery disease ( 32469254) Serum metabolite levels ( 33031748)	Diastolic blood pressure ( 27841878 30487518) Hypertension ( 30487518 32709000) Mean arterial pressure ( 29403010 30487518) Medication use (diuretics) ( 31015401) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Pulse pressure ( 30487518) Systolic blood pressure ( 27841878 29403010 30487518 30578418)
Interacting Genes		5 interacting genes: CYCS CYP11A1 CYP11B2 FDXR PRKAB2	3 interacting genes: CYP11A1 CYP11B1 FDX1
Entrez ID		2230	1585
HPRD ID		00059	00492
Ensembl ID		ENSG00000137714	ENSG00000179142
Uniprot IDs		P10109	P19099
PDB IDs		3N9Y 3N9Z 3NA0 3NA1 3P1M 7M8I	4DVQ 4FDH 4ZGX 6XZ8 6XZ9 7M8I 7M8V
Enriched GO Terms of Interacting Partners?		C21-steroid Hormone Biosynthetic Process Steroid Metabolic Process Glucocorticoid Biosynthetic Process Steroid Biosynthetic Process Cortisol Metabolic Process Ketone Metabolic Process Alcohol Metabolic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Steroid Hydroxylase Activity Glucocorticoid Metabolic Process Regulation Of RIG-I Signaling Pathway Negative Regulation Of Necroptotic Process Cholesterol Metabolic Process Heme Binding Sterol Metabolic Process Negative Regulation Of Programmed Necrotic Cell Death Olefinic Compound Metabolic Process C21-steroid Hormone Metabolic Process Mitochondrial Inner Membrane Steroid Hormone Biosynthetic Process Regulation Of Necroptotic Process Non-canonical NF-kappaB Signal Transduction Ketone Biosynthetic Process Hormone Metabolic Process Regulation Of Programmed Necrotic Cell Death Hormone Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Lipid Biosynthetic Process Oxidoreductase Activity Lipid Metabolic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Cholesterol Monooxygenase (side-chain-cleaving) Activity Ferredoxin-NADP+ Reductase Activity 11-cis-retinol Dehydrogenase (NAD+) Activity Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Monooxygenase Activity FBXO Family Protein Binding Steroid 11-beta-monooxygenase Activity Regulation Of Blood Volume By Renal Aldosterone Corticosterone 18-monooxygenase Activity Negative Regulation Of Postsynaptic Density Organization MHC Class Ib Protein Complex Binding Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein-containing Complex Binding Small Molecule Metabolic Process Positive Regulation Of Protein K48-linked Ubiquitination	Hormone Biosynthetic Process Cholesterol Metabolic Process Iron Ion Binding Glucocorticoid Biosynthetic Process Steroid Biosynthetic Process Cortisol Metabolic Process Sterol Metabolic Process C21-steroid Hormone Biosynthetic Process Hormone Metabolic Process Glucocorticoid Metabolic Process Steroid Metabolic Process Alcohol Metabolic Process C21-steroid Hormone Metabolic Process Steroid Hormone Biosynthetic Process Lipid Biosynthetic Process Regulation Of Hormone Levels Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Ketone Metabolic Process Cellular Response To Oxygen-containing Compound Heme Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Cholesterol Monooxygenase (side-chain-cleaving) Activity Olefinic Compound Metabolic Process Lipid Metabolic Process Cellular Response To Peptide Hormone Stimulus Steroid 11-beta-monooxygenase Activity Corticosterone 18-monooxygenase Activity P450-containing Electron Transport Chain Aldosterone Biosynthetic Process Small Molecule Metabolic Process Mineralocorticoid Biosynthetic Process Mitochondrion Aldosterone Metabolic Process Cortisol Biosynthetic Process Response To Peptide Hormone Cellular Response To Hormone Stimulus Mitochondrial Matrix Mitochondrial Inner Membrane Vitamin D Metabolic Process Cellular Response To Potassium Ion Cellular Response To Forskolin Steroid Hydroxylase Activity Oxidoreductase Activity Response To Forskolin Regulation Of Biological Quality Response To Potassium Ion Response To Hormone 2 Iron, 2 Sulfur Cluster Binding Ketone Biosynthetic Process
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