FDX1 and CYP11A1

Number of citations of the paper that reports this interaction (PMID 1917982)
18

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		FDX1	CYP11A1
Gene Name		ferredoxin 1	cytochrome P450, family 11, subfamily A, polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix Mitochondrial Crista Perikaryon
	Molecular Function	Iron Ion Binding Electron Carrier Activity 2 Iron, 2 Sulfur Cluster Binding	Iron Ion Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Cholesterol Binding Heme Binding
	Biological Process	C21-steroid Hormone Biosynthetic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Hormone Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process	C21-steroid Hormone Biosynthetic Process Progesterone Biosynthetic Process Estrogen Biosynthetic Process Xenobiotic Metabolic Process Mating Behavior Steroid Metabolic Process Cholesterol Metabolic Process Response To Salt Stress Response To Gamma Radiation Schwann Cell Differentiation Sterol Metabolic Process Response To Insecticide Biphenyl Metabolic Process Dibenzo-p-dioxin Metabolic Process Phenol-containing Compound Metabolic Process Phthalate Metabolic Process Cerebellum Development Hippocampus Development Response To Vitamin E Leydig Cell Differentiation Response To L-ascorbic Acid Response To Genistein Vitamin D Metabolic Process Response To Drug Response To Hydrogen Peroxide Response To Alkaloid Small Molecule Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Fractalkine Metabolic Process Response To Corticosterone Oxidation-reduction Process Granulosa Cell Differentiation Maternal Process Involved In Female Pregnancy Response To Fungicide Testosterone Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Antibiotic Cellular Response To Cadmium Ion Cellular Response To CAMP Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Mitochondrial iron-sulfur cluster biogenesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Electron transport from NADPH to Ferredoxin Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs		Mitotane
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CYCS CYP11A1 CYP11B2 FDXR PRKAB2	5 interactors: CYP11B2 FDX1 SMAD2 SMAD3 SMAD9
Entrez ID		2230	1583
HPRD ID		00059	00326
Ensembl ID		ENSG00000137714	ENSG00000140459
Uniprot IDs		P10109	P05108
PDB IDs		3N9Y 3N9Z 3NA0 3NA1 3P1M	3N9Y 3N9Z 3NA0 3NA1
Enriched GO Terms of Interacting Partners?		C21-steroid Hormone Biosynthetic Process C21-steroid Hormone Metabolic Process Hormone Biosynthetic Process Cellular Ketone Metabolic Process Steroid Biosynthetic Process Oxidation-reduction Process Lipid Biosynthetic Process Sterol Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Hormone Metabolic Process Small Molecule Metabolic Process Steroid Metabolic Process Regulation Of Hormone Levels Alcohol Metabolic Process Lipid Metabolic Process Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Cholesterol Metabolic Process Cellular Response To Metal Ion Cellular Response To Inorganic Substance Response To Genistein Regulation Of Blood Volume By Renal Aldosterone Response To Hormone Granulosa Cell Differentiation Aldosterone Biosynthetic Process Cortisol Biosynthetic Process Fractalkine Metabolic Process Response To Reactive Oxygen Species Mitochondrial Electron Transport, Cytochrome C To Oxygen Response To Fungicide Chemokine Metabolic Process Testosterone Biosynthetic Process Response To Hydroxyisoflavone Mineralocorticoid Biosynthetic Process Cellular Response To Potassium Ion Phthalate Metabolic Process Dibenzo-p-dioxin Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Biphenyl Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Carnitine Shuttle Cellular Response To Stimulus Cellular Response To Peptide Response To Metal Ion Response To Potassium Ion Glucocorticoid Biosynthetic Process Response To L-ascorbic Acid	Primary MiRNA Processing SMAD Protein Complex Assembly Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Paraxial Mesoderm Morphogenesis Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development Cellular Response To Transforming Growth Factor Beta Stimulus Nodal Signaling Pathway Response To Transforming Growth Factor Beta Embryonic Foregut Morphogenesis Foregut Morphogenesis Paraxial Mesoderm Development Production Of MiRNAs Involved In Gene Silencing By MiRNA C21-steroid Hormone Biosynthetic Process Pericardium Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Hormone Levels C21-steroid Hormone Metabolic Process Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Kidney Development Gene Silencing By MiRNA Cellular Response To DsRNA Renal System Development Posttranscriptional Gene Silencing Urogenital System Development SMAD Protein Signal Transduction Positive Regulation Of Stem Cell Differentiation Cellular Response To Organic Cyclic Compound Hormone Biosynthetic Process Regulation Of Epithelial To Mesenchymal Transition Embryonic Cranial Skeleton Morphogenesis Digestive Tract Morphogenesis Gene Silencing By RNA Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To DsRNA Endoderm Development Embryonic Pattern Specification Mesoderm Formation Skeletal System Development Mesoderm Morphogenesis Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Gene Silencing
Tagcloud ?			aas aass abused anabolic androgenic arr19 dax1 disturbed enanthate gnrhr hsd17b4 hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo
Tagcloud (Difference) ?			aas aass abused anabolic androgenic arr19 dax1 disturbed enanthate gnrhr hsd17b4 hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo
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