PHACTR1 and ACTA1

Number of citations of the paper that reports this interaction (PMID 15107502)
31

Data Source:
HPRD (in vivo)

		PHACTR1	ACTA1
Gene Name		phosphatase and actin regulator 1	actin, alpha 1, skeletal muscle
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cell Junction Synapse	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Binding Protein Phosphatase Inhibitor Activity Protein Phosphatase 1 Binding Protein Phosphatase Type 1 Regulator Activity	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Actomyosin Structure Organization Actin Cytoskeleton Reorganization Negative Regulation Of Catalytic Activity Stress Fiber Assembly Cell Motility	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS		Blood pressure ( 22763476) Coronary artery calcification ( 22144573) Coronary heart disease ( 22745674 21846871 22751097 21378988 21378990) Hip geometry ( 17903296) Migraine ( 22683712) Myocardial infarction (early onset) ( 19198609)
Protein-Protein Interactions		2 interactors: ACTA1 PPP1CA	107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		221692	58
HPRD ID		12283	00030
Ensembl ID			ENSG00000143632
Uniprot IDs		Q9C0D0	P68133 Q5T8M7
PDB IDs			1T44
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Fiber Adaptation Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Regulation Of Glycogen Catabolic Process Skeletal Muscle Adaptation Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Skeletal Muscle Fiber Development Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Response To Abiotic Stimulus Myotube Cell Development Response To Lithium Ion Regulation Of Glycogen Biosynthetic Process Muscle Filament Sliding Actin-myosin Filament Sliding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Glycogen Metabolic Process Actin-mediated Cell Contraction Muscle Fiber Development Myotube Differentiation Glycogen Metabolic Process Actin Filament-based Movement Tissue Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To External Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Myofibril Assembly Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Triglyceride Metabolic Process Regulation Of Circadian Rhythm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Glucose Metabolic Process Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Actomyosin Structure Organization Anatomical Structure Morphogenesis Response To Organic Substance Energy Reserve Metabolic Process Skeletal Muscle Tissue Development Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Lipid Catabolic Process Skeletal Muscle Organ Development Cell Growth Regulation Of Carbohydrate Metabolic Process	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly
Tagcloud ?		actin attribute basic beta1 ccg depleted emt follows import importin mal mkl1 monomeric motifs mrtf msenchymal myocardin nb nls nlss pool prevents proposal proximity pull rho rpel sepharose vital	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Difference) ?		actin attribute basic beta1 ccg depleted emt follows import importin mal mkl1 monomeric motifs mrtf msenchymal myocardin nb nls nlss pool prevents proposal proximity pull rho rpel sepharose vital	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Intersection) ?