PHACTR1

Description		phosphatase and actin regulator 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Synapse
	Molecular Function	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding
	Biological Process	Cerebral Cortex Development Actin Cytoskeleton Organization Actomyosin Structure Organization Stress Fiber Assembly Cell Motility Dendrite Arborization Regulation Of Neuron Migration
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30643258 30679032) Basophil percentage of white cells ( 32888494) Blood pressure ( 22763476) Cervical artery dissection ( 25420145) Chronotype ( 26835600 30696823) Coronary artery calcification ( 22144573 23394302) Coronary artery disease ( 32469254 26343387 28714974 33020668 24262325 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 22751097 22745674 21846871 21378990 21378988) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Diastolic blood pressure ( 27618447) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gait speed in old age ( 28077804) Hand grip strength ( 29691431) Headache ( 29397368) Hip geometry ( 17903296) HIV-1 viral setpoint ( 26039976) Hypertension ( 27618447) Idiopathic dilated cardiomyopathy ( 29495422) Medication use (antimigraine preparations) ( 31015401) Metabolite levels ( 23823483) Migraine ( 27182965 27322543 23793025 22683712) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Morning person ( 30696823) Myocardial infarction ( 33532862 26343387) Myocardial infarction (early onset) ( 19198609) Pulse pressure ( 30578418 28135244 27841878 27618447) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Spontaneous coronary artery dissection ( 32374345 32887874) Systolic blood pressure ( 30578418 27841878 27618447)
Interacting Genes		6 interacting genes: ACTA1 C14orf119 CBX8 LINC00839 PPP1CA SNCA
Entrez ID		221692
HPRD ID		12283
Ensembl ID		ENSG00000112137
Uniprot IDs		A0A6Q8PFA8 A0A6Q8PG87 A0A6Q8PGC2 A0A8I5QJF9 B4DHU0 Q9C0D0
PDB IDs		6ZEE 6ZEF 6ZEG 6ZEH 6ZEI 6ZEJ
Enriched GO Terms of Interacting Partners?		Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Striated Muscle Thin Filament Skeletal Muscle Thin Filament Assembly Mesenchyme Migration RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Presynapse Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex Positive Regulation Of Small Molecule Metabolic Process Double-strand Break Repair Via Alternative Nonhomologous End Joining RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Generation Of Precursor Metabolites And Energy Postsynapse Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Negative Regulation Of Dopamine Metabolic Process Mitochondrial ATP Synthesis Coupled Electron Transport Negative Regulation Of Serotonin Uptake Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Transporter Regulator Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Catecholamine Metabolic Process Cellular Response To Oxidative Stress Regulation Of Norepinephrine Uptake Response To Iron(II) Ion Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Dopamine Biosynthetic Process Regulation Of Serotonin Uptake Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Ubiquitin-protein Transferase Activator Activity Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Histone H3K27me3 Reader Activity Cellular Response To Chemical Stress Actin Cytoskeleton Catecholamine Uptake
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