MARCH8 and UBE2H

Number of citations of the paper that reports this interaction (PMID 14722266)
68

Data Source:
BioGRID (pull down)

		MARCH8	UBE2H
Gene Name		membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2H
Image
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane	Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity MHC Class II Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of MHC Class II Biosynthetic Process	Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		5 interactors: CD86 IL1RAP UBE2D1 UBE2D3 UBE2H	57 interactors: BRAP BYSL CBLC CD99 DTX3 DTX3L DZIP3 EPS15 HDAC6 HIST2H2AA3 JADE1 LRSAM1 MARCH1 MARCH10 MARCH2 MARCH4 MARCH8 MKRN3 NEURL1 NHLRC1 POLL POLM RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 UBA1 UBASH3B UBOX5 UBR2
Entrez ID		220972	7328
HPRD ID		17466	03052
Ensembl ID		ENSG00000165406	ENSG00000186591
Uniprot IDs		H0Y7C6 Q5T0T0	A4D1L5 P62256
PDB IDs		2D8S	2Z5D
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of Innate Immune Response Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Innate Immune Response Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Defense Response Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process BMP Signaling Pathway Toll-like Receptor 4 Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Positive Regulation Of Immune Response Negative Regulation Of T Cell Anergy Positive Regulation Of Lymphotoxin A Biosynthetic Process Cellular Response To Oxygen Levels Immune System Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Interleukin-4 Biosynthetic Process Cellular Macromolecule Catabolic Process Regulation Of Immune Response Transcription Initiation From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Organic Substance Response To Transforming Growth Factor Beta Interleukin-2 Biosynthetic Process DNA-templated Transcription, Initiation	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Protein Autoubiquitination Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Monoubiquitination Regulation Of Viral Release From Host Cell Metabolic Process Histone Ubiquitination Protein Catabolic Process Histone Monoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Regulation Of Viral Entry Into Host Cell Cellular Macromolecule Catabolic Process Cellular Process Negative Regulation Of Protein Metabolic Process Histone Modification Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Viral Process Regulation Of ERBB Signaling Pathway Protein Trimerization Aggresome Assembly Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K6-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Histone H2A Monoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Chromatin Modification Negative Regulation Of Cellular Protein Metabolic Process Proteolysis Catabolic Process Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Negative Regulation Of Viral Entry Into Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?			0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 ctsf dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1
Tagcloud (Difference) ?			0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 ctsf dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1
Tagcloud (Intersection) ?