MARCHF8 and TMEM14C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MARCHF8	TMEM14C
Description		membrane associated ring-CH-type finger 8	transmembrane protein 14C
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity MHC Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Transmembrane Transporter Activity
	Biological Process	Protein Polyubiquitination Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response Protein Ubiquitination	Heme Biosynthetic Process Mitochondrial Transport Erythrocyte Differentiation Transmembrane Transport Regulation Of Heme Biosynthetic Process
Pathways
Drugs
Diseases
GWAS			Itch intensity from mosquito bite adjusted by bite size ( 28199695) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)
Interacting Genes		16 interacting genes: ARR3 CD86 CGAS CYB5B FA2H FUBP3 GOSR2 HNRNPA1 HNRNPK IL1RAP TMEM14C UBC UBE2D1 UBE2D3 UBE2H VAMP2	51 interacting genes: AQP6 ARL13B BCL2L13 BIK CLDN5 COMT COQ9 CPLANE2 CREB3 CREB3L1 CYB5R3 EBP ELOVL7 FAM209A GJB1 GORAB GPR152 GPX8 HSD17B13 KASH5 LMNA LNX1 MARCHF8 MFF MMGT1 MTERF3 MUC1 NCAPH2 NCR3LG1 PDZK1IP1 PLIN3 RCHY1 SAR1A SDC3 SHANK3 SLC10A6 SLC18A1 SLC35H1 SSMEM1 STX1A SYT1 TMEM14B TMEM31 TMEM35A TMEM52B TMEM79 TMEM86B TMX2 VSIR ZDHHC15 ZFYVE27
Entrez ID		220972	51522
HPRD ID		17466	15524
Ensembl ID		ENSG00000165406	ENSG00000111843
Uniprot IDs		Q5T0T0	Q9P0S9
PDB IDs		2D8S	2LOS
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination	Membrane Endoplasmic Reticulum Membrane Identical Protein Binding Protein Binding Mitochondrial Membrane Endoplasmic Reticulum Clathrin-sculpted Monoamine Transport Vesicle Membrane Organelle Organization Norepinephrine Transport
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