MARCHF8 and CYB5B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MARCHF8	CYB5B
Description		membrane associated ring-CH-type finger 8	cytochrome b5 type B
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Nitric-oxide Synthase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity MHC Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Heme Binding Metal Ion Binding Nitrite Reductase (NO-forming) Activity
	Biological Process	Protein Polyubiquitination Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response Protein Ubiquitination	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress
Pathways			Sphingolipid de novo biosynthesis eNOS activation Phase I - Functionalization of compounds
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS			Blood osmolality (transformed sodium) ( 28360221) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 29403010 30993211)
Interacting Genes		16 interacting genes: ARR3 CD86 CGAS CYB5B FA2H FUBP3 GOSR2 HNRNPA1 HNRNPK IL1RAP TMEM14C UBC UBE2D1 UBE2D3 UBE2H VAMP2	51 interacting genes: AHNAK2 APP AQP6 BIK BNIP3L BTNL9 CD33 CD79A CGRRF1 CLDN7 CLN8 CPLX4 CREB3 EBP ERGIC3 FAM209A FAM210B FKBP7 FNDC9 FRMD3 GJB5 GPR152 IGSF9 KCNK5 KIR2DL3 LMNA MARCHF8 MFF MUC1 NDUFAF2 PDZK1IP1 PHACTR3 PLPP4 REEP4 RETREG3 SDHAF4 SLC10A1 SLC10A6 SLC16A2 SLC35H1 SLC39A9 SLC60A2 SLC71A2 STOM STX1A SYT1 TMEM139 TMEM237 TMEM35A TMEM41A TMEM86B
Entrez ID		220972	80777
HPRD ID		17466	13106
Ensembl ID		ENSG00000165406	ENSG00000103018
Uniprot IDs		Q5T0T0	O43169
PDB IDs		2D8S	3NER
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination	Membrane
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