MARCH8

Gene Name		membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity MHC Class II Protein Binding
	Biological Process	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of MHC Class II Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978 19862010) Red blood cell traits ( 23222517)
Protein-protein Interactions		5 interactors: CD86 IL1RAP UBE2D1 UBE2D3 UBE2H
Entrez ID		220972
HPRD ID		17466
Ensembl ID		ENSG00000165406
Uniprot IDs		H0Y7C6 Q5T0T0
PDB IDs		2D8S
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of Innate Immune Response Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Innate Immune Response Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Defense Response Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process BMP Signaling Pathway Toll-like Receptor 4 Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Positive Regulation Of Immune Response Negative Regulation Of T Cell Anergy Positive Regulation Of Lymphotoxin A Biosynthetic Process Cellular Response To Oxygen Levels Immune System Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Interleukin-4 Biosynthetic Process Cellular Macromolecule Catabolic Process Regulation Of Immune Response Transcription Initiation From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Organic Substance Response To Transforming Growth Factor Beta Interleukin-2 Biosynthetic Process DNA-templated Transcription, Initiation
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