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MARCH8 and CD86
Number of citations of the paper that reports this interaction (PMID
12582153
)
34
Data Source:
HPRD
(in vitro, in vivo)
MARCH8
CD86
Gene Name
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
CD86 molecule
Image
Gene Ontology Annotations
Cellular Component
Lysosome
Lysosomal Membrane
Endosome
Integral Component Of Membrane
Cytoplasmic Vesicle Membrane
Early Endosome Membrane
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Intracellular Membrane-bounded Organelle
Extracellular Vesicular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Zinc Ion Binding
Ligase Activity
MHC Class II Protein Binding
Receptor Activity
Receptor Binding
Protein Binding
Coreceptor Activity
Biological Process
Protein Polyubiquitination
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Negative Regulation Of MHC Class II Biosynthetic Process
Response To Yeast
Toll-like Receptor Signaling Pathway
T Cell Proliferation Involved In Immune Response
Negative Regulation Of T Cell Anergy
Immune Response
Epidermal Growth Factor Receptor Signaling Pathway
Cell-cell Signaling
Aging
Positive Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Viral Process
T Cell Costimulation
Response To Interferon-gamma
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Activated T Cell Proliferation
T Cell Activation
B Cell Activation
Response To Drug
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Lymphotoxin A Biosynthetic Process
Positive Regulation Of Interleukin-2 Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interleukin-4 Biosynthetic Process
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Defense Response To Virus
Cellular Response To Lipopolysaccharide
Cellular Response To Metal Ion
Cellular Response To Cytokine Stimulus
Pathways
Signaling by the B Cell Receptor (BCR)
Costimulation by the CD28 family
Signaling by FGFR in disease
PIP3 activates AKT signaling
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
PI-3K cascade
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Innate Immune System
Signaling by PDGF
Signalling by NGF
DAP12 interactions
GAB1 signalosome
CD28 co-stimulation
CTLA4 inhibitory signaling
CD28 dependent PI3K/Akt signaling
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by ERBB4
Signaling by Overexpressed Wild-Type EGFR in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
CD28 dependent Vav1 pathway
Signaling by FGFR
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Drugs
Antithymocyte globulin
Abatacept
Belatacept
Diseases
GWAS
Mean corpuscular hemoglobin (
20139978
)
Mean corpuscular volume (
20139978
19862010
)
Red blood cell traits (
23222517
)
Multiple sclerosis (
22190364
21833088
)
Protein-Protein Interactions
5 interactors:
CD86
IL1RAP
UBE2D1
UBE2D3
UBE2H
6 interactors:
CD28
CD80
CTLA4
ECE2
MARCH8
PARP1
Entrez ID
220972
942
HPRD ID
17466
03011
Ensembl ID
ENSG00000165406
ENSG00000114013
Uniprot IDs
H0Y7C6
Q5T0T0
A8K632
P42081
PDB IDs
2D8S
1I85
1NCN
Enriched GO Terms of Interacting Partners
?
Protein K48-linked Ubiquitination
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Protein Polyubiquitination
Positive Regulation Of Innate Immune Response
Innate Immune Response
Protein K11-linked Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Regulation Of Innate Immune Response
Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Defense Response
Regulation Of DNA-templated Transcription In Response To Stress
TRIF-dependent Toll-like Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
BMP Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To Organic Substance
Positive Regulation Of Immune Response
Negative Regulation Of T Cell Anergy
Positive Regulation Of Lymphotoxin A Biosynthetic Process
Cellular Response To Oxygen Levels
Immune System Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Interleukin-4 Biosynthetic Process
Cellular Macromolecule Catabolic Process
Regulation Of Immune Response
Transcription Initiation From RNA Polymerase II Promoter
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Immune System Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Organic Substance
Response To Transforming Growth Factor Beta
Interleukin-2 Biosynthetic Process
DNA-templated Transcription, Initiation
T Cell Costimulation
Regulation Of T Cell Proliferation
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Interleukin-2 Biosynthetic Process
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Interleukin-2 Biosynthetic Process
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of Interleukin-2 Production
Immune System Process
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Positive Regulation Of Cytokine Biosynthetic Process
Immune Response-regulating Signaling Pathway
Regulation Of Cell Activation
Positive Regulation Of T Cell Proliferation
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Cytokine Biosynthetic Process
Regulation Of Cell Adhesion
Positive Regulation Of Lymphocyte Proliferation
Positive Regulation Of Mononuclear Cell Proliferation
Positive Regulation Of Immune Response
Regulation Of T Cell Differentiation
Phosphatidylinositol-mediated Signaling
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Adaptive Immune Response
Regulation Of Lymphocyte Differentiation
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Growth Rate
Protein Poly-ADP-ribosylation
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process
Regulation Of Immune Response
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process
Response To Fibroblast Growth Factor
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Adaptive Immune Response
Positive Regulation Of Immune System Process
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Regulatory T Cell Differentiation
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of T-helper 1 Cell Differentiation
Tagcloud
?
amixl
atl
bc
blast
burkitt
cd54
cd58
cd80
cll
cml
costimulatory
crisis
dr
granular
hematological
hla
immuno
lgl
lymphoblastic
lymphocytic
lymphoma
malignancies
manipulating
modality
myeloblastic
neoplastic
ph1
philadelphia
sharply
Tagcloud (Difference)
?
amixl
atl
bc
blast
burkitt
cd54
cd58
cd80
cll
cml
costimulatory
crisis
dr
granular
hematological
hla
immuno
lgl
lymphoblastic
lymphocytic
lymphoma
malignancies
manipulating
modality
myeloblastic
neoplastic
ph1
philadelphia
sharply
Tagcloud (Intersection)
?