FAH and ADAMTSL4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FAH	ADAMTSL4
Gene Name		fumarylacetoacetate hydrolase (fumarylacetoacetase)	ADAMTS-like 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Cellular_component Interstitial Matrix Endoplasmic Reticulum Lumen
	Molecular Function	Fumarylacetoacetase Activity Metal Ion Binding	Protease Binding Metalloendopeptidase Activity Protein Binding
	Biological Process	Arginine Catabolic Process L-phenylalanine Catabolic Process Tyrosine Catabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process	Protein O-linked Glycosylation Proteolysis Apoptotic Process Extracellular Matrix Organization Protein O-linked Fucosylation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Phenylalanine and tyrosine catabolism Metabolism of amino acids and derivatives	Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
Drugs
Diseases
GWAS			Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		6 interactors: ADAMTSL4 EGFR KRTAP10-8 KRTAP5-9 SERTAD1 TCF4	106 interactors: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 C19orf66 C6orf165 CATSPER1 CCDC26 CHCHD2 CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL1P1 GNE GNMT GOLGA8EP HGF HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587
Entrez ID		2184	54507
HPRD ID		02040	18237
Ensembl ID		ENSG00000103876	ENSG00000143382
Uniprot IDs		P16930	F8WAD0 Q6UY14 Q9UFG7
PDB IDs
Enriched GO Terms of Interacting Partners?		Digestive Tract Morphogenesis Positive Regulation Of Protein Kinase B Signaling Regulation Of Smooth Muscle Cell Proliferation Glial Cell Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Nucleocytoplasmic Transport Alkanesulfonate Metabolic Process Regulation Of Protein Kinase B Signaling Digestive Tract Development Digestive System Development Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Catenin Import Into Nucleus Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Astrocyte Activation Positive Regulation Of Intracellular Protein Transport Regulation Of Cell Cycle Glial Cell Differentiation Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Activation Of Phospholipase A2 Activity Maintenance Of DNA Repeat Elements Skin Development Epithelium Development Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of Intracellular Transport Gliogenesis Response To Cobalamin Response To UV-A Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Hindgut Morphogenesis Regulation Of Intracellular Protein Transport Epidermis Development Embryonic Genitalia Morphogenesis Response To Hydroxyisoflavone Ossification Regulation Of Epithelial Cell Proliferation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Myoblast Fate Commitment Positive Regulation Of Transcription, DNA-templated Secretory Granule Localization Positive Regulation Of Protein Transport Positive Regulation Of Catenin Import Into Nucleus Regulation Of Apoptotic Process Regulation Of Cell Proliferation Hindgut Morphogenesis Protein O-linked Fucosylation Positive Regulation Of Macromolecule Biosynthetic Process	Multicellular Organismal Development Keratinization Organ Development Developmental Process Keratinocyte Differentiation System Development Anatomical Structure Development Epidermis Development Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Cell Differentiation Sensory Organ Development Response To Organic Substance Organic Anion Transport Positive Regulation Of Neuron Projection Regeneration Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Cellular Response To Thyroid Hormone Stimulus MRNA Transcription From RNA Polymerase II Promoter Skin Development Positive Regulation Of Transcription, DNA-templated Transepithelial Transport Semicircular Canal Development Positive Regulation Of Gene Expression Regulation Of Branching Involved In Salivary Gland Morphogenesis MRNA Transcription Response To Thyroid Hormone Negative Regulation Of Hydrolase Activity Cell Differentiation Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?		adequately alcoholic busulfan chimeric chimerism conditioning enabling examples exceeded fails frgn fumarylacetoacetate hematolymphoid hepatocytes hepatotoxicity hepatotropic humanization humanized hydrolase il2rg involve kupffer livers pathophysiologic rag2 repopulation steatohepatitis transplanted upa	abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Difference) ?		adequately alcoholic busulfan chimeric chimerism conditioning enabling examples exceeded fails frgn fumarylacetoacetate hematolymphoid hepatocytes hepatotoxicity hepatotropic humanization humanized hydrolase il2rg involve kupffer livers pathophysiologic rag2 repopulation steatohepatitis transplanted upa	abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Intersection) ?