FAH and CHRDL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAH	CHRDL2
Description		fumarylacetoacetate hydrolase	chordin like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Catalytic Activity Fumarylacetoacetase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding BMP Binding
	Biological Process	L-arginine Catabolic Process L-phenylalanine Catabolic Process L-tyrosine Catabolic Process Lipid Metabolic Process Aromatic Amino Acid Metabolic Process Homogentisate Catabolic Process	Ossification Cell Differentiation Negative Regulation Of BMP Signaling Pathway System Development Cartilage Development
Pathways		Tyrosine catabolism
Drugs		Fumaric acid Acetoacetic acid 4-[Hydroxy-[Methyl-Phosphinoyl]]-3-Oxo-Butanoic Acid
Diseases		Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS		Blood protein levels ( 30072576)	Allergic rhinitis ( 25085501) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Microalbuminuria ( 26631737) Spine bone size ( 31053729)
Interacting Genes		9 interacting genes: ADAMTSL4 CHRDL2 EGFR KRTAP10-8 KRTAP13-3 KRTAP5-9 PLEKHF2 SERTAD1 TCF4	21 interacting genes: BANP BMP2 BMP4 BMP5 BMP6 BMP7 CHRD ENKD1 FAH FAM90A1 GDF5 GPSM3 HOXA1 INHBA MAPRE3 OTX1 PIK3R3 POU4F2 SLIT1 ZNF417 ZNF587
Entrez ID		2184	25884
HPRD ID		02040	09881
Ensembl ID		ENSG00000103876	ENSG00000054938
Uniprot IDs		A0A384P5L6 P16930	Q6WN34
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament	Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction BMP Receptor Binding BMP Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Activator Complex Cartilage Development Cytokine Activity Ossification Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Differentiation Ameloblast Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Positive Regulation Of Neuron Differentiation Skeletal System Development Regulation Of Aldosterone Biosynthetic Process Regulation Of Neuron Differentiation Positive Regulation Of Bone Mineralization Endocardial Cushion Formation Type B Pancreatic Cell Development Positive Regulation Of Biomineral Tissue Development Regulation Of Cell Differentiation Positive Regulation Of Ossification Heart Development Negative Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Epithelial Cell Differentiation Protein Serine/threonine Kinase Activator Activity Regulation Of Cartilage Development Positive Regulation Of Osteoblast Differentiation Regulation Of Locomotion Regulation Of Ketone Biosynthetic Process Regulation Of Bone Mineralization Regulation Of Hormone Biosynthetic Process Anatomical Structure Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Neural Fold Elevation Formation Positive Regulation Of Cell Differentiation Regulation Of Animal Organ Formation Odontogenesis Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Aldosterone Biosynthetic Process
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