PDHX and DLD

Number of citations of the paper that reports this interaction (PMID 16263718)
13

Data Source:
HPRD (in vitro)

		PDHX	DLD
Gene Name		pyruvate dehydrogenase complex, component X	dihydrolipoamide dehydrogenase
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix	Nucleoplasm Mitochondrion Mitochondrial Matrix Cilium Acrosomal Matrix
	Molecular Function	Transferase Activity, Transferring Acyl Groups	Dihydrolipoyl Dehydrogenase Activity Mercury (II) Reductase Activity Mercury Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Pyruvate Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process	Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Electron Transport, NADH To Ubiquinone Proteolysis Lysine Catabolic Process Gastrulation Branched-chain Amino Acid Catabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Nitrogen Compound Metabolic Process Regulation Of Membrane Potential Cellular Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Sperm Capacitation Detoxification Of Mercury Ion
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Branched-chain amino acid catabolism Signaling by Retinoic Acid Lysine catabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of amino acids and derivatives Citric acid cycle (TCA cycle)
Drugs			NADH Nicotinamide-Adenine-Dinucleotide Flavin-Adenine Dinucleotide
Diseases
GWAS			Ulcerative colitis ( 23128233 20228799 19122664)
Protein-Protein Interactions		8 interactors: ACTN1 AGTRAP DLAT DLD EP300 EWSR1 PDHB PDK2	3 interactors: OGDH PDHX SLC2A4
Entrez ID		8050	1738
HPRD ID		02002	02006
Ensembl ID		ENSG00000110435	ENSG00000091140
Uniprot IDs		E9PB14 O00330	B4DT69 E9PEX6 P09622
PDB IDs		1ZY8 2DNC 2F5Z 2F60	1ZMC 1ZMD 1ZY8 2F5Z 3RNM
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Lipid Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cellular Respiration Monocarboxylic Acid Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Metabolic Process Generation Of Precursor Metabolites And Energy Organic Acid Metabolic Process Histone H2B Acetylation Signal Transduction By P53 Class Mediator Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Phosphorus Metabolic Process N-terminal Peptidyl-lysine Acetylation Protein Localization To Tight Junction Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Tubulin Deacetylation Intrinsic Apoptotic Signaling Pathway Regulation Of Metabolic Process Acetyl-CoA Biosynthetic Process Angiotensin-activated Signaling Pathway Lysine Catabolic Process Protein Localization To Cell Junction Positive Regulation By Host Of Viral Transcription Detoxification Of Mercury Ion Carbohydrate Metabolic Process N-terminal Protein Amino Acid Acetylation Response To Hypoxia Regulation Of Cellular Process Small Molecule Metabolic Process Apoptotic Signaling Pathway Sperm Capacitation Actin Crosslink Formation Branched-chain Amino Acid Catabolic Process Regulation Of Androgen Receptor Signaling Pathway Acetyl-CoA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Mercury Ion N-terminal Protein Amino Acid Modification	Pyruvate Metabolic Process Amylopectin Biosynthetic Process Olfactory Bulb Mitral Cell Layer Development Succinyl-CoA Metabolic Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb Small Molecule Metabolic Process Lysine Catabolic Process Glucose Import Pyramidal Neuron Development Pyramidal Neuron Differentiation Monocarboxylic Acid Metabolic Process Thalamus Development 2-oxoglutarate Metabolic Process Striatum Development Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate NADH Metabolic Process Regulation Of Acyl-CoA Biosynthetic Process Subpallium Development Hexose Transmembrane Transport Cellular Response To Osmotic Stress Forebrain Neuron Development Tricarboxylic Acid Cycle Olfactory Bulb Development Citrate Metabolic Process Brown Fat Cell Differentiation Carboxylic Acid Metabolic Process Olfactory Lobe Development Carbohydrate Metabolic Process NAD Metabolic Process Tricarboxylic Acid Metabolic Process Organic Acid Metabolic Process Carbohydrate Transmembrane Transport Aerobic Respiration Forebrain Neuron Differentiation Acyl-CoA Metabolic Process Cerebellar Cortex Development Glucose Transport Hippocampus Development Hexose Transport Forebrain Generation Of Neurons Nicotinamide Nucleotide Metabolic Process Regulation Of Fatty Acid Metabolic Process Response To Osmotic Stress Diencephalon Development Dicarboxylic Acid Metabolic Process Glycolytic Process Limbic System Development Cellular Response To Hypoxia Telencephalon Cell Migration Cellular Response To Decreased Oxygen Levels
Tagcloud ?		antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm lgals8 libraries otud6b probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238	a25 anisomycin ap b42 calyculin changing cm cotransfection dexamethasone dichloroisocoumarin dithiocarbamate flanking fos heterogenous interferon jak jun microm nitrite nos okadaic oxide panepoxydone phenylarsine pyrrolidine resting stat1alpha tyrphostin unlikely
Tagcloud (Difference) ?		antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm lgals8 libraries otud6b probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238	a25 anisomycin ap b42 calyculin changing cm cotransfection dexamethasone dichloroisocoumarin dithiocarbamate flanking fos heterogenous interferon jak jun microm nitrite nos okadaic oxide panepoxydone phenylarsine pyrrolidine resting stat1alpha tyrphostin unlikely
Tagcloud (Intersection) ?