PDHX

Name	pyruvate dehydrogenase complex component X
Structure
Interactors	11 interactors: ACTN1 AGTRAP CIDEB DLAT DLD EP300 EWSR1 HSD17B10 OGT PDHB PDK2
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Pyruvate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Acyltransferase Activity
	Biological Process	Pyruvate Decarboxylation To Acetyl-CoA
Pathways	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid PDH complex synthesizes acetyl-CoA from PYR
Diseases	Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS	Bone mineral density (hip) ( 30172743 ) Heel bone mineral density ( 30598549 ) Systemic lupus erythematosus ( 28714469 ) Type 2 diabetes ( 30297969 ) Uterine fibroids ( 30194396 31649266 )
Entrez ID	8050
HPRD ID	02002
Ensembl ID	ENSG00000110435
Uniprot IDs	A0A8C8MSB2 O00330
PDB IDs	1ZY8 2DNC 2F5Z 2F60 6H60
GO Terms Enriched among Interactors ?	Pyruvate Dehydrogenase Complex Pyruvate Decarboxylation To Acetyl-CoA Acetyl-CoA Biosynthetic Process Pyruvate Metabolic Process Acetyl-CoA Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Mitochondrial Matrix Monosaccharide Metabolic Process Regulation Of Gluconeogenesis Monocarboxylic Acid Metabolic Process Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Regulation Of Glucose Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Acetyltransferase Activity Branched-chain Amino Acid Catabolic Process Carbohydrate Metabolic Process Amide Biosynthetic Process Platelet Formation Small Molecule Metabolic Process Histone Acetyltransferase Complex Branched-chain Amino Acid Metabolic Process Purine-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Tricarboxylic Acid Cycle Response To Nutrient Levels Mitochondrion Cellular Response To Nutrient Nucleoside Phosphate Metabolic Process Carboxylic Acid Catabolic Process Purine-containing Compound Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Sulfur Compound Metabolic Process Dihydrolipoyl Dehydrogenase (NADH) Activity 2-oxoglutarate Decarboxylation To Succinyl-CoA Acetyltransferase Complex Peptidyl-lysine Propionylation Regulation Of Glycolytic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone Crotonyltransferase Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity