PDHX and PDK2

Number of citations of the paper that reports this interaction (PubMedID 12816949)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PDHX	PDK2
Description		pyruvate dehydrogenase complex component X	pyruvate dehydrogenase kinase 2
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Pyruvate Dehydrogenase Complex	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Pyruvate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Acyltransferase Activity	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity
	Biological Process	Pyruvate Decarboxylation To Acetyl-CoA	Glucose Metabolic Process Regulation Of Gluconeogenesis Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Stress Cellular Response To Reactive Oxygen Species Glucose Homeostasis Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid PDH complex synthesizes acetyl-CoA from PYR	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs			4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (2R)-N-{4-[Ethyl(phenyl)sulfamoyl]-2-methylphenyl}-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Bone mineral density (hip) ( 30172743) Heel bone mineral density ( 30598549) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30297969) Uterine fibroids ( 30194396 31649266)
Interacting Genes		11 interacting genes: ACTN1 AGTRAP CIDEB DLAT DLD EP300 EWSR1 HSD17B10 OGT PDHB PDK2	10 interacting genes: AKT1 DLAT HIC2 HTT ISOC2 PDHA1 PDHX PDK1 SGK1 VSIG4
Entrez ID		8050	5164
HPRD ID		02002	03955
Ensembl ID		ENSG00000110435	ENSG00000005882
Uniprot IDs		A0A8C8MSB2 O00330	Q15119
PDB IDs		1ZY8 2DNC 2F5Z 2F60 6H60	2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8 4MP2 4MP7 4MPC 4MPE 4MPN 4V25 4V26 5J6A 5J71 5M4K 5M4M 5M4N 5M4P 6LIL 6LIN 6LIO 6TMP 6TMQ 6TMZ 6TN0 6TN2 7EA0 7EAS 7EBH 7VBU 7VBV 7VBX 8ZM1 8ZM2
Enriched GO Terms of Interacting Partners?		Pyruvate Dehydrogenase Complex Pyruvate Decarboxylation To Acetyl-CoA Acetyl-CoA Biosynthetic Process Pyruvate Metabolic Process Acetyl-CoA Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Mitochondrial Matrix Monosaccharide Metabolic Process Regulation Of Gluconeogenesis Monocarboxylic Acid Metabolic Process Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Regulation Of Glucose Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Acetyltransferase Activity Branched-chain Amino Acid Catabolic Process Carbohydrate Metabolic Process Amide Biosynthetic Process Platelet Formation Small Molecule Metabolic Process Histone Acetyltransferase Complex Branched-chain Amino Acid Metabolic Process Purine-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Tricarboxylic Acid Cycle Response To Nutrient Levels Mitochondrion Cellular Response To Nutrient Nucleoside Phosphate Metabolic Process Carboxylic Acid Catabolic Process Purine-containing Compound Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Sulfur Compound Metabolic Process Dihydrolipoyl Dehydrogenase (NADH) Activity 2-oxoglutarate Decarboxylation To Succinyl-CoA Acetyltransferase Complex Peptidyl-lysine Propionylation Regulation Of Glycolytic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone Crotonyltransferase Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity	Pyruvate Dehydrogenase Complex Pyruvate Decarboxylation To Acetyl-CoA Acetyl-CoA Biosynthetic Process Dihydrolipoyllysine-residue Acetyltransferase Activity Glucose Metabolic Process Acetyl-CoA Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Pyruvate Metabolic Process Mitochondrion Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Carbohydrate Metabolic Process Phosphate-containing Compound Metabolic Process Mitochondrial Matrix Amide Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Tricarboxylic Acid Cycle Positive Regulation Of Cilium Assembly Protein Kinase Activity Positive Regulation Of Transporter Activity Purine-containing Compound Biosynthetic Process T Cell Costimulation Kinase Activity Sulfur Compound Metabolic Process Regulation Of TRNA Methylation Protein Destabilization Nucleoside Phosphate Biosynthetic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Cilium Assembly Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Organelle Assembly Regulation Of T Cell Activation Response To Insulin-like Growth Factor Stimulus Regulation Of Leukocyte Cell-cell Adhesion Protein Serine Kinase Activity Mammalian Oogenesis Stage Protein Phosphorylation Regulation Of Glucose Metabolic Process Kinase Binding TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Small Molecule Metabolic Process Phosphorylation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Protein Serine/threonine Kinase Activity Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
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