PDHX and DLAT

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (pull down, biochemical, two hybrid)
HPRD (in vitro)

		PDHX	DLAT
Gene Name		pyruvate dehydrogenase complex, component X	dihydrolipoamide S-acetyltransferase
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Transferase Activity, Transferring Acyl Groups	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding
	Biological Process	Pyruvate Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process	Glucose Metabolic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH Radicicol Dihydrolipoic Acid
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACTN1 AGTRAP DLAT DLD EP300 EWSR1 PDHB PDK2	8 interactors: PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PRKD3
Entrez ID		8050	1737
HPRD ID		02002	10578
Ensembl ID		ENSG00000110435	ENSG00000150768
Uniprot IDs		E9PB14 O00330	P10515 Q86YI5
PDB IDs		1ZY8 2DNC 2F5Z 2F60	1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Lipid Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cellular Respiration Monocarboxylic Acid Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Metabolic Process Generation Of Precursor Metabolites And Energy Organic Acid Metabolic Process Histone H2B Acetylation Signal Transduction By P53 Class Mediator Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Phosphorus Metabolic Process N-terminal Peptidyl-lysine Acetylation Protein Localization To Tight Junction Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Tubulin Deacetylation Intrinsic Apoptotic Signaling Pathway Regulation Of Metabolic Process Acetyl-CoA Biosynthetic Process Angiotensin-activated Signaling Pathway Lysine Catabolic Process Protein Localization To Cell Junction Positive Regulation By Host Of Viral Transcription Detoxification Of Mercury Ion Carbohydrate Metabolic Process N-terminal Protein Amino Acid Acetylation Response To Hypoxia Regulation Of Cellular Process Small Molecule Metabolic Process Apoptotic Signaling Pathway Sperm Capacitation Actin Crosslink Formation Branched-chain Amino Acid Catabolic Process Regulation Of Androgen Receptor Signaling Pathway Acetyl-CoA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Mercury Ion N-terminal Protein Amino Acid Modification	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Monosaccharide Metabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Phosphorus Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Carbohydrate Metabolic Process Carbohydrate Metabolic Process Small Molecule Metabolic Process Acetyl-CoA Biosynthetic Process Insulin Receptor Signaling Pathway Acetyl-CoA Metabolic Process Protein Phosphorylation Glucose Homeostasis Cellular Response To Insulin Stimulus Tricarboxylic Acid Cycle Response To Insulin Cellular Response To Fatty Acid Citrate Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Phosphorylation Tricarboxylic Acid Metabolic Process Aerobic Respiration Acyl-CoA Metabolic Process Regulation Of PH Response To Fatty Acid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Response To Hormone Stimulus Cellular Response To Stress Phosphate-containing Compound Metabolic Process Coenzyme Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Metabolic Process Cellular Respiration
Tagcloud ?		antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm lgals8 libraries otud6b probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238	accumulate acyltransferase adapts bckadh branched dehydrogenase dihydrolipoamide helps immunodeficient infectives intermediates keto lipoamide lpd lpdc metabolize nutritionally pdh pdha pdhb pdhc peroxidase peroxynitrite persist phenocopies pnr pyruvate resist upregulates
Tagcloud (Difference) ?		antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm lgals8 libraries otud6b probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238	accumulate acyltransferase adapts bckadh branched dehydrogenase dihydrolipoamide helps immunodeficient infectives intermediates keto lipoamide lpd lpdc metabolize nutritionally pdh pdha pdhb pdhc peroxidase peroxynitrite persist phenocopies pnr pyruvate resist upregulates
Tagcloud (Intersection) ?