PDHX and PDHB

Number of citations of the paper that reports this interaction (PMID 7864652)
3

Data Source:
HPRD (in vivo)

		PDHX	PDHB
Gene Name		pyruvate dehydrogenase complex, component X	pyruvate dehydrogenase (lipoamide) beta
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex Extracellular Vesicular Exosome
	Molecular Function	Transferase Activity, Transferring Acyl Groups	Pyruvate Dehydrogenase Activity Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding
	Biological Process	Pyruvate Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs			Pyruvic acid NADH
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACTN1 AGTRAP DLAT DLD EP300 EWSR1 PDHB PDK2	15 interactors: ANXA7 CDKN1A DLAT FCER1A GNB2 GRB7 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RCC1 TRIM63 TSC22D1
Entrez ID		8050	5162
HPRD ID		02002	01530
Ensembl ID		ENSG00000110435	ENSG00000168291
Uniprot IDs		E9PB14 O00330	P11177
PDB IDs		1ZY8 2DNC 2F5Z 2F60	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Lipid Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cellular Respiration Monocarboxylic Acid Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Metabolic Process Generation Of Precursor Metabolites And Energy Organic Acid Metabolic Process Histone H2B Acetylation Signal Transduction By P53 Class Mediator Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Phosphorus Metabolic Process N-terminal Peptidyl-lysine Acetylation Protein Localization To Tight Junction Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Tubulin Deacetylation Intrinsic Apoptotic Signaling Pathway Regulation Of Metabolic Process Acetyl-CoA Biosynthetic Process Angiotensin-activated Signaling Pathway Lysine Catabolic Process Protein Localization To Cell Junction Positive Regulation By Host Of Viral Transcription Detoxification Of Mercury Ion Carbohydrate Metabolic Process N-terminal Protein Amino Acid Acetylation Response To Hypoxia Regulation Of Cellular Process Small Molecule Metabolic Process Apoptotic Signaling Pathway Sperm Capacitation Actin Crosslink Formation Branched-chain Amino Acid Catabolic Process Regulation Of Androgen Receptor Signaling Pathway Acetyl-CoA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Mercury Ion N-terminal Protein Amino Acid Modification	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Monocarboxylic Acid Metabolic Process Regulation Of Fatty Acid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glucose Metabolic Process Generation Of Precursor Metabolites And Energy G1/S Transition Of Mitotic Cell Cycle Hemostasis Response To Organic Cyclic Compound Cellular Respiration Hexose Metabolic Process Carboxylic Acid Metabolic Process Regulation Of Body Fluid Levels Monosaccharide Metabolic Process Mitotic Cell Cycle Phase Transition Cellular Response To Ionizing Radiation Organic Acid Metabolic Process Regulation Of Cellular Process Cell Cycle Phase Transition Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Type I Hypersensitivity Regulation Of Vesicle-mediated Transport Positive Regulation Of Phosphorylation Glycolytic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Collagen Catabolic Process Positive Regulation Of Protein Modification Process Small Molecule Metabolic Process Blood Coagulation Positive Regulation Of MAPK Cascade Response To Hormone Negative Regulation Of Synaptic Vesicle Exocytosis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Calcium-independent Cell-matrix Adhesion Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Acetyl-CoA Biosynthetic Process From Pyruvate Positive Regulation Of Protein Kinase Activity Response To Organic Substance
Tagcloud ?		antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm lgals8 libraries otud6b probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238	actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?		antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm lgals8 libraries otud6b probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238	actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?