BLOC1S6 and NDN

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		BLOC1S6	NDN
Description		biogenesis of lysosomal organelles complex 1 subunit 6	necdin, MAGE family member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Endosome Cytosol Focal Adhesion Membrane Transport Vesicle BLOC-1 Complex Cytoplasmic Vesicle Filamentous Actin Cell-cell Contact Zone Contractile Ring Presynapse Axon Cytoplasm Microvesicle	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Protein-containing Complex Cell Projection Perikaryon
	Molecular Function	Protein Binding Syntaxin Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding Molecular Adaptor Activity	DNA Binding Protein Binding Gamma-tubulin Binding Promoter-specific Chromatin Binding
	Biological Process	Kidney Development Bradykinin Biosynthetic Process Respiratory System Process Endothelium Development Amino Acid Metabolic Process Glutamate Metabolic Process Glutamine Metabolic Process Protein Targeting Lipid Metabolic Process Phospholipid Metabolic Process Blood Coagulation Memory Anterograde Axonal Transport Protein Secretion Response To Xenobiotic Stimulus Gene Expression Response To Activity Synaptic Vesicle Docking Dentate Gyrus Development Hypothalamus Development Melanocyte Differentiation Lung Development Neuron Projection Development Melanosome Transport Melanosome Organization Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Intracellular Nitric Oxide Homeostasis Multicellular Organism Growth Endosome To Melanosome Transport Vasodilation Circadian Sleep/wake Cycle Pigmentation ATP Metabolic Process Adenosine Metabolic Process Intracellular Transport Lung Alveolus Development Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Positive Regulation Of Pigment Cell Differentiation Actin Filament Bundle Assembly Lipid Homeostasis Cilium Assembly Membrane Fusion Cellular Response To Epidermal Growth Factor Stimulus Protein Transmembrane Transport Response To Acetylcholine	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Respiratory System Process Regulation Of DNA-templated Transcription Axonogenesis Axonal Fasciculation Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Glial Cell Migration Post-embryonic Development Sensory Perception Of Pain Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neurotrophin TRK Receptor Signaling Pathway Neuron Development Axon Extension Multicellular Organismal-level Homeostasis Genomic Imprinting
Pathways		Golgi Associated Vesicle Biogenesis	Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases			Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS			Body size at age 10 ( 32376654) Depressive symptoms (SSRI exposure interaction) ( 25649181) HDL cholesterol levels ( 32203549) Parkinson's disease (age of onset) ( 33884653) Plasma anti-thyroid peroxidase levels ( 29678681) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		49 interacting genes: ABI2 AGGF1 ANK1 APP BLOC1S1 BLOC1S2 BLOC1S4 C4orf46 CCDC136 CCDC22 CCHCR1 CCR2 CDK5R1 CEP44 CORO6 DCTN2 DTNBP1 EPS8 EXOC8 HAUS1 IFT20 INSYN1 KRT13 KRT72 LURAP1 MED21 MLPH NDC80 NDN NTAQ1 NUP62 OLFM2 PLEKHA5 PLEKHF2 RABGEF1 RINT1 SKA1 SLC4A1 SMN1 SMN2 SNAPIN STX11 STX12 STX1A SYCE3 TPM1 TPM3 TRAK1 WASHC3	47 interacting genes: APBB1IP ARSL BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EEF1AKMT1 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 IRS4 LAX1 LPXN MIER2 MKRN2 MYG1 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PALS2 PJA1 PPARGC1A PPFIA1 SERTAD3 SIRT1 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B
Entrez ID		26258	4692
HPRD ID		16055	03667
Ensembl ID		ENSG00000104164	ENSG00000182636
Uniprot IDs		B3KY40 H3BST1 Q9UL45	Q99608 X5D982
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Localization BLOC-1 Complex Establishment Of Localization In Cell Intracellular Transport Cellular Localization Axo-dendritic Transport Organelle Organization Establishment Of Organelle Localization Microtubule-based Process Establishment Of Vesicle Localization Anterograde Synaptic Vesicle Transport Vesicle Organization Transport Along Microtubule Vesicle Localization Vesicle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Microtubule-based Transport Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Protein Transport Establishment Of Protein Localization Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Vesicle-mediated Transport Anterograde Axonal Transport Organelle Transport Along Microtubule Intracellular Protein Localization Cytoplasm Cytosol Neuron Projection Neuron Projection Development Regulation Of Lysosome Size BORC Complex Microtubule-based Movement Exocytosis Growth Cone Cytoskeleton Organization Perikaryon Regulation Of Endosome Size Cytoplasmic Side Of Lysosomal Membrane Cell Projection Organization Supramolecular Fiber Organization Regulation Of Supramolecular Fiber Organization Centrosome Secretion By Cell Regulation Of Vesicle Size Lysosome Localization PTB Domain Binding	Cis-regulatory Region Sequence-specific DNA Binding Axo-dendritic Transport Circadian Rhythm Transport Along Microtubule Cellular Response To Hypoxia Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Neuron Apoptotic Process Cytoskeleton-dependent Intracellular Transport Axon Cytoplasm Microtubule-based Transport Axonal Transport Circadian Regulation Of Gene Expression Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Response To Insulin Stimulus Cytoplasm Cellular Response To Decreased Oxygen Levels DNA-binding Transcription Activator Activity Promoter-specific Chromatin Binding Embryonic Placenta Development Cellular Homeostasis Regulation Of MiRNA Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Rhythmic Process Cellular Response To Oxygen Levels Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Intracellular Chemical Homeostasis Organelle Transport Along Microtubule Intracellular Glucose Homeostasis Regulation Of Fibroblast Proliferation Positive Regulation Of Biosynthetic Process Stress-induced Premature Senescence Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex MRNA Metabolic Process PML Body Anterograde Axonal Transport Nuclear Receptor Binding Connective Tissue Replacement Microtubule-based Process Intracellular Oxygen Homeostasis Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Gene Expression Protein Domain Specific Binding
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