CRTC2 and CDC23

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRTC2	CDC23
Description		CREB regulated transcription coactivator 2	cell division cycle 23
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Extracellular Exosome	Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Gluconeogenesis Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cellular Response To CAMP	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Chromosome Alignment Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age at first birth ( 27798627 34211149) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Autism spectrum disorder or schizophrenia ( 28540026) Resting heart rate ( 27798624)
Interacting Genes		15 interacting genes: ATPAF2 CCDC57 CDC23 CREB1 MFHAS1 NEDD4 PPP3CA PRKAA1 SIK1 SIK2 SIK3 SUFU YWHAB YWHAG YWHAZ	78 interacting genes: ANAPC10 ANKRD11 APOL1 ATRIP BCAS3 BEGAIN BYSL C21orf91 CBY2 CCDC125 CCDC24 CCDC33 CDC16 CDT1 CEP44 CERCAM COIL CRACR2A CRTC2 CTBP1 CYB5R2 DCLK1 DEPDC1B DISC1 DLX6-AS1 EIF5A2 FAM9B FOXN1 GORASP2 GPRASP3 GTPBP8 HEMK1 IHO1 INCA1 INO80E INPP5J KCTD6 KRT36 LHX3 LZTS1 LZTS2 MAGED1 MAPK3 NAB2 NRBF2 NUP54 OPTN PFKFB4 PIH1D2 PNMA5 POU6F2 PROSER3 PRPF31 PRR22 RAC1 RAD54B RBM15B RBP3 RBPMS RSL24D1 RUNX1T1 SIAH1 SLC52A2 SMARCB1 SMUG1 SORBS3 SOX5 SPAG8 SSX2IP STX2 SUV39H1 TEPSIN TNIP1 TRIM27 TSC22D4 UBE2S USP54 ZMAT1
Entrez ID		200186	8697
HPRD ID		12347	07221
Ensembl ID		ENSG00000160741	ENSG00000094880
Uniprot IDs		Q53ET0	Q9UJX2
PDB IDs		4HTM	4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Protein Modification Process Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Negative Regulation Of Protein Localization Regulation Of TORC1 Signaling Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of TOR Signaling Protein Sequestering Activity Phosphorylation Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Negative Regulation Of Cell Communication Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Signaling Cellular Response To Glucose Starvation Protein Localization To Lysosome Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Targeting Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell TORC1 Signaling Negative Regulation Of Biosynthetic Process Protein Domain Specific Binding Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell TOR Signaling Positive Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Immune Response To Tumor Cell Protein Localization To Vacuole Phosphate-containing Compound Metabolic Process Regulation Of Protein Localization Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Modification-dependent Protein Catabolic Process Negative Regulation Of Protein Import Into Nucleus Positive Regulation Of Immune Response To Tumor Cell Protein Catabolic Process Negative Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Nucleocytoplasmic Transport
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