CRTC2 and SIK3

Number of citations of the paper that reports this interaction (PubMedID 16306228)
0

Data Source:
HPRD (in vivo, in vitro)

		CRTC2	SIK3
Description		CREB regulated transcription coactivator 2	SIK family kinase 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Extracellular Exosome	Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Gluconeogenesis Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cellular Response To CAMP	Microtubule Cytoskeleton Organization Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling
Pathways		Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs			Fostamatinib
Diseases
GWAS		Age at first birth ( 27798627 34211149) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Allergic rhinitis ( 30013184) Apolipoprotein B levels ( 32203549) Body mass index ( 31978080) Cholesterol ( 31902109) Delirium ( 29631748) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) HDL cholesterol ( 24886709 31170924) HDL cholesterol levels ( 32203549) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Hearing function ( 25060954) Mean platelet volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 30382898) Non-accommodative esotropia ( 30098192) Platelet count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to Vitamin E supplementation ( 22437554) Sum eosinophil basophil counts ( 27863252) Triglyceride levels ( 29615537 32203549) Triglyceride levels x fish oil supplementation interaction (2df) ( 33760818) Triglycerides ( 24886709)
Interacting Genes		15 interacting genes: ATPAF2 CCDC57 CDC23 CREB1 MFHAS1 NEDD4 PPP3CA PRKAA1 SIK1 SIK2 SIK3 SUFU YWHAB YWHAG YWHAZ	6 interacting genes: CRTC2 HDAC5 PRKACA TRAF1 TRIP6 YWHAZ
Entrez ID		200186	23387
HPRD ID		12347	11121
Ensembl ID		ENSG00000160741	ENSG00000160584
Uniprot IDs		Q53ET0	H0Y4E8 Q9Y2K2
PDB IDs		4HTM	8OKU 8R4O 8R4Q 8R4U 8R4V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Protein Modification Process Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Negative Regulation Of Protein Localization Regulation Of TORC1 Signaling Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of TOR Signaling Protein Sequestering Activity Phosphorylation Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Negative Regulation Of Cell Communication Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Signaling Cellular Response To Glucose Starvation Protein Localization To Lysosome Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Targeting Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell TORC1 Signaling Negative Regulation Of Biosynthetic Process Protein Domain Specific Binding Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell TOR Signaling Positive Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Immune Response To Tumor Cell Protein Localization To Vacuole Phosphate-containing Compound Metabolic Process Regulation Of Protein Localization Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Modification-dependent Protein Catabolic Process Negative Regulation Of Protein Import Into Nucleus Positive Regulation Of Immune Response To Tumor Cell Protein Catabolic Process Negative Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Nucleocytoplasmic Transport
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