CRTC2 and PPP3CA

Number of citations of the paper that reports this interaction (PMID 15454081)
140

Data Source:
HPRD (in vivo, in vitro)

		CRTC2	PPP3CA
Gene Name		CREB regulated transcription coactivator 2	protein phosphatase 3, catalytic subunit, alpha isozyme
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcineurin Complex Z Disc Sarcolemma
	Molecular Function	Protein Binding CAMP Response Element Binding Protein Binding	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Gluconeogenesis Transcription, DNA-templated Viral Process Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Histone H3-K9 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Homotetramerization Toxin Transport	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Transition Between Fast And Slow Fiber Dephosphorylation Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Regulation Of Synaptic Transmission Positive Regulation Of NFAT Protein Import Into Nucleus Response To Calcium Ion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways			Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Blood pressure ( 22763476) Corneal structure ( 21979947)
Protein-Protein Interactions		9 interactors: PPP3CA PRKAA1 SIK1 SIK2 SIK3 UBC YWHAB YWHAG YWHAZ	24 interactors: AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 MARCH7 MYOZ2 MYOZ3 PPP3R1 PRKCZ RCAN1 RCAN2 SOD1 SYNJ1
Entrez ID		200186	5530
HPRD ID		12347	00234
Ensembl ID		ENSG00000160741	ENSG00000138814
Uniprot IDs		Q53ET0	Q08209
PDB IDs		4HTM	1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Phosphate-containing Compound Metabolic Process Phosphorylation Intracellular Signal Transduction Cellular Response To Insulin Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Cell Death Response To Insulin Cellular Response To Peptide Hormone Stimulus Regulation Of Apoptotic Process Cellular Response To Peptide Regulation Of Protein Localization Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Cell Death Response To Organonitrogen Compound Protein Targeting Regulation Of Intracellular Transport Response To Peptide Hormone Cellular Response To Organic Substance Cellular Response To Organonitrogen Compound Regulation Of Signaling Response To Peptide Insulin Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Signaling Cell Communication Response To Organic Substance Mitotic Cell Cycle Phase Transition Positive Regulation Of Transport Regulation Of Protein Kinase Activity Cell Cycle Phase Transition Intracellular Transport Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Negative Regulation Of Lipid Biosynthetic Process Regulation Of Kinase Activity	Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signaling Cell Communication Behavior Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Organic Cyclic Compound Calcineurin-NFAT Signaling Cascade Response To Histamine Single-organism Behavior Regulation Of Neuron Death Cellular Response To Stimulus Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Signal Transduction Inositol Phosphate-mediated Signaling Cellular Response To Ammonium Ion Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Gamma-aminobutyric Acid Signaling Pathway Regulation Of Cell Activation Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Neurological System Process Positive Regulation Of Cellular Metabolic Process Regulation Of T Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Stimulus Synaptic Transmission Negative Regulation Of Apoptotic Process Cell-cell Signaling Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Transport Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Death
Tagcloud ?		autocrine calcitonin cgrp cofactor competes costimulatory creb crtc3 engagement enhancing exhibits glycoprotein herpesvirus hsv lymphotoxin macrophage macrophages mediator modulates nerves neuroimmunological neuropeptide shape sphingosine sphk1 stimulatory sustained tlr4	adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Difference) ?		autocrine calcitonin cgrp cofactor competes costimulatory creb crtc3 engagement enhancing exhibits glycoprotein herpesvirus hsv lymphotoxin macrophage macrophages mediator modulates nerves neuroimmunological neuropeptide shape sphingosine sphk1 stimulatory sustained tlr4	adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Intersection) ?