CRTC2 and PPP3CA

Number of citations of the paper that reports this interaction (PubMedID 15454081)
0

Data Source:
HPRD (in vitro, in vivo)

		CRTC2	PPP3CA
Description		CREB regulated transcription coactivator 2	protein phosphatase 3 catalytic subunit alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Cytoplasmic Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Z Disc Sarcolemma Cell Projection Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity ATPase Binding
	Biological Process	Gluconeogenesis Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cellular Response To CAMP	G1/S Transition Of Mitotic Cell Cycle Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Epidermis Development Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Dephosphorylation Calcium-mediated Signaling Negative Regulation Of Signaling Keratinocyte Differentiation Positive Regulation Of Cell Migration Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Wound Healing Positive Regulation Of Activated T Cell Proliferation T Cell Activation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Saliva Secretion Skeletal Muscle Fiber Development Dendrite Morphogenesis Negative Regulation Of Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Response To Calcium Ion Excitatory Postsynaptic Potential Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Peptidyl-serine Dephosphorylation Renal Sodium Ion Absorption Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glomerulus Development Renal Filtration Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2	DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs			Myristic acid
Diseases
GWAS		Age at first birth ( 27798627 34211149) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Anorexia nervosa ( 24514567) Bitter non-alcoholic beverage consumption ( 31046077) Blood pressure ( 22763476) Chronotype ( 30696823) Corneal structure ( 21979947) Trunk fat mass ( 28552196) Vitiligo ( 27723757)
Interacting Genes		15 interacting genes: ATPAF2 CCDC57 CDC23 CREB1 MFHAS1 NEDD4 PPP3CA PRKAA1 SIK1 SIK2 SIK3 SUFU YWHAB YWHAG YWHAZ	44 interacting genes: AATK ABI2 AKAP5 AMPH ATP2B4 BAD BCL2 BTG3 C16orf74 CABIN1 CASP3 CEBPA CRTC2 DCPH1 FAM167A FGFR4 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 ITPKB KCNIP3 KLHL3 MARCHF7 MYOZ2 MYOZ3 OGT PLAC8 PPP3R1 PRKCZ PTK7 RCAN1 RCAN2 RYK SHANK2 SNCA SOD1 STUB1 SYNJ1 UBC UBE4B UNC119
Entrez ID		200186	5530
HPRD ID		12347	00234
Ensembl ID		ENSG00000160741	ENSG00000138814
Uniprot IDs		Q53ET0	A0A0S2Z4B5 A0A0S2Z4C6 Q08209
PDB IDs		4HTM	1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z 4Q5U 5C1V 5SVE 6NUC 6NUF 6NUU 6UUQ 9B9G
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Protein Modification Process Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Negative Regulation Of Protein Localization Regulation Of TORC1 Signaling Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of TOR Signaling Protein Sequestering Activity Phosphorylation Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Negative Regulation Of Cell Communication Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Signaling Cellular Response To Glucose Starvation Protein Localization To Lysosome Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Targeting Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell TORC1 Signaling Negative Regulation Of Biosynthetic Process Protein Domain Specific Binding Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell TOR Signaling Positive Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Immune Response To Tumor Cell Protein Localization To Vacuole Phosphate-containing Compound Metabolic Process Regulation Of Protein Localization Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Modification-dependent Protein Catabolic Process Negative Regulation Of Protein Import Into Nucleus Positive Regulation Of Immune Response To Tumor Cell Protein Catabolic Process Negative Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Nucleocytoplasmic Transport	Protein Phosphatase 2B Binding Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction Calcineurin-mediated Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Metal Ion Transport Cell Junction Organization Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Synapse Organization Regulation Of Calcium-mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell Activation Cell Junction Assembly Calcium-mediated Signaling BAD-BCL-2 Complex Synapse Assembly Negative Regulation Of Calcineurin-NFAT Signaling Cascade GABA-gated Chloride Ion Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Signal Transduction Chemical Homeostasis Regulation Of Monoatomic Ion Transport Tissue Morphogenesis GABA-A Receptor Activity GABA-A Receptor Complex Chemical Synaptic Transmission Regulation Of Membrane Potential Homeostatic Process Negative Regulation Of Calcium-mediated Signaling Response To Metal Ion Trans-synaptic Signaling Z Disc Regulation Of Calcium Ion Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inhibitory Synapse Assembly Synaptic Signaling Regulation Of Calcium Ion Transmembrane Transport Response To Oxidative Stress Gamma-aminobutyric Acid Signaling Pathway Regulation Of Lymphocyte Activation Postsynaptic Specialization Membrane Negative Regulation Of Apoptotic Process
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