GGN and SH3RF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GGN	SH3RF1
Description		gametogenetin	SH3 domain containing ring finger 1
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Golgi Apparatus Cytosol Lamellipodium Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	MAP-kinase Scaffold Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Double-strand Break Repair Gamete Generation Spermatogenesis Cell Differentiation	MAPK Cascade Neuron Migration Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Response To Aldosterone Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			RHOV GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)
Interacting Genes		25 interacting genes: ABI2 BAG3 BRCA1 CYSRT1 ECT2 FANCL GGNBP1 GGNBP2 GOLGA2 GRB2 HOMER3 HSF2BP KRT40 KRTAP2-3 KRTAP2-4 KRTAP5-9 MTUS2 NCK2 OAZ3 OSTF1 RACK1 SH3KBP1 SH3RF1 WWP2 ZMYND19	69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1
Entrez ID		199720	57630
HPRD ID		17036	15335
Ensembl ID		ENSG00000179168	ENSG00000154447
Uniprot IDs		Q86UU5	Q7Z6J0
PDB IDs			7NZC 7NZD
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Regulation Of Cytoskeleton Organization Cytoplasm Cellular Response To Ionizing Radiation Protein Autoubiquitination Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Intermediate Filament Signaling Adaptor Activity Positive Regulation Of Intracellular Protein Transport Keratin Filament Regulation Of Protein Transport Positive Regulation Of Protein Transport Cytoskeletal Anchor Activity Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Actin Filament Organization Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Metabolic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Binding Gamete Generation Response To Ionizing Radiation Positive Regulation Of Intracellular Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport Regulation Of Endoplasmic Reticulum Unfolded Protein Response Vesicle Membrane Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Protein Import Into Nucleus Guanyl-nucleotide Exchange Factor Adaptor Activity	SH3 Domain Binding MAP Kinase Kinase Kinase Activity Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly JUN Kinase Kinase Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Protein Autophosphorylation Ubiquitin Conjugating Enzyme Activity Lamellipodium Negative Regulation Of Membrane Tubulation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Actin Filament-based Process Regulation Of Protein Modification Process Focal Adhesion Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Modification-dependent Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Proteolysis Involved In Protein Catabolic Process T Cell Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Actin Cytoskeleton Organization Actin Polymerization Or Depolymerization Actomyosin Contractile Ring Assembly JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Apoptotic Process Cell Surface Receptor Signaling Pathway Signal Transduction Protein Polymerization Programmed Cell Death Cell Death Positive Regulation Of Protein Phosphorylation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Cell Communication Protein Modification Process Cytoplasm
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