GGN and OSTF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GGN	OSTF1
Description		gametogenetin	osteoclast stimulating factor 1
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Cytoplasm Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding SH3 Domain Binding
	Biological Process	Double-strand Break Repair Gamete Generation Spermatogenesis Cell Differentiation	Ossification Signal Transduction
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS			Allergic rhinitis ( 25085501) Glucose homeostasis traits ( 25524916) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Resting-state electroencephalogram vigilance ( 29703947) Systemic sclerosis ( 30247649) Urinary magnesium-to-creatinine ratio ( 29093028)
Interacting Genes		25 interacting genes: ABI2 BAG3 BRCA1 CYSRT1 ECT2 FANCL GGNBP1 GGNBP2 GOLGA2 GRB2 HOMER3 HSF2BP KRT40 KRTAP2-3 KRTAP2-4 KRTAP5-9 MTUS2 NCK2 OAZ3 OSTF1 RACK1 SH3KBP1 SH3RF1 WWP2 ZMYND19	51 interacting genes: AGR2 APP BORCS6 CBL CBLB CCDC33 CRX CTDSP1 CUEDC1 DPPA4 DTX3 EFS ERRFI1 FASLG FBXO7 GAPDH GGN HES7 HTT KHDRBS1 KLHL42 LATS1 LMNA MAPK6 MED19 MEOX2 NFYC NUTM1 NUTM2F PBX4 PICK1 PRRG4 REL SDCBP SF1 SF3A2 SMN1 SNW1 SOCS7 SYNGAP1 TRIB3 TRIM54 VPS37B WASF1 WASHC1 WASL YPEL3 ZBTB42 ZBTB7B ZNF655 ZNF688
Entrez ID		199720	26578
HPRD ID		17036	17808
Ensembl ID		ENSG00000179168	ENSG00000134996
Uniprot IDs		Q86UU5	Q92882
PDB IDs			1X2K 1ZLM 3EHQ 3EHR
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Regulation Of Cytoskeleton Organization Cytoplasm Cellular Response To Ionizing Radiation Protein Autoubiquitination Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Intermediate Filament Signaling Adaptor Activity Positive Regulation Of Intracellular Protein Transport Keratin Filament Regulation Of Protein Transport Positive Regulation Of Protein Transport Cytoskeletal Anchor Activity Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Actin Filament Organization Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Metabolic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Binding Gamete Generation Response To Ionizing Radiation Positive Regulation Of Intracellular Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport Regulation Of Endoplasmic Reticulum Unfolded Protein Response Vesicle Membrane Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Protein Import Into Nucleus Guanyl-nucleotide Exchange Factor Adaptor Activity	Regulation Of Receptor-mediated Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway SH3 Domain Binding Regulation Of ERBB Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Synapse Structure Or Activity Regulation Of Receptor Internalization Nucleus Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway MRNA 3'-splice Site Recognition Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Transcription By RNA Polymerase II Establishment Of Organelle Localization Regulation Of Actin Nucleation Neuron Projection Organization Cytoskeleton-dependent Intracellular Transport Regulation Of Endocytosis Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Localization Spliceosomal Complex Assembly Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Protein Binding Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Arp2/3 Complex Binding Regulation Of Supramolecular Fiber Organization Regulation Of Metabolic Process Regulation Of Plasma Membrane Organization Negative Regulation Of Alpha-beta T Cell Proliferation Localization Within Membrane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endocytosis Regulation Of Cell Communication Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway
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