GGN and ECT2

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		GGN	ECT2
Description		gametogenetin	epithelial cell transforming 2
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Anchoring Junction Mitotic Spindle Centralspindlin Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Double-strand Break Repair Gamete Generation Spermatogenesis Cell Differentiation	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		25 interacting genes: ABI2 BAG3 BRCA1 CYSRT1 ECT2 FANCL GGNBP1 GGNBP2 GOLGA2 GRB2 HOMER3 HSF2BP KRT40 KRTAP2-3 KRTAP2-4 KRTAP5-9 MTUS2 NCK2 OAZ3 OSTF1 RACK1 SH3KBP1 SH3RF1 WWP2 ZMYND19	39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN HACL2 KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2
Entrez ID		199720	1894
HPRD ID		17036	11860
Ensembl ID		ENSG00000179168	ENSG00000114346
Uniprot IDs		Q86UU5	Q9H8V3
PDB IDs			3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Regulation Of Cytoskeleton Organization Cytoplasm Cellular Response To Ionizing Radiation Protein Autoubiquitination Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Intermediate Filament Signaling Adaptor Activity Positive Regulation Of Intracellular Protein Transport Keratin Filament Regulation Of Protein Transport Positive Regulation Of Protein Transport Cytoskeletal Anchor Activity Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Actin Filament Organization Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Metabolic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Binding Gamete Generation Response To Ionizing Radiation Positive Regulation Of Intracellular Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport Regulation Of Endoplasmic Reticulum Unfolded Protein Response Vesicle Membrane Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Protein Import Into Nucleus Guanyl-nucleotide Exchange Factor Adaptor Activity	Cytosol Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination
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