GGN and FANCL

Number of citations of the paper that reports this interaction (PubMedID 12574169)
0

Data Source:
HPRD (in vivo, two hybrid)

		GGN	FANCL
Description		gametogenetin	FA complementation group L
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Nuclear Body Fanconi Anaemia Nuclear Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Double-strand Break Repair Gamete Generation Spermatogenesis Cell Differentiation	DNA Repair Protein Monoubiquitination DNA Damage Response Gamete Generation Protein Ubiquitination Interstrand Cross-link Repair Regulation Of Cell Population Proliferation
Pathways			Fanconi Anemia Pathway PKR-mediated signaling
Drugs
Diseases			Fanconi anemia
GWAS			Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 20935630 31453325) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Epilepsy ( 30531953 25087078) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Generalized epilepsy ( 30531953) HDL cholesterol levels ( 32203549) Hirschsprung disease ( 27702942) Initial pursuit acceleration ( 29064472) Irritable mood ( 29500382) Obesity ( 23563607) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Schizophrenia ( 29483656 25056061) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Triglyceride levels ( 32203549) Type 2 diabetes ( 30718926) Waist circumference ( 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		25 interacting genes: ABI2 BAG3 BRCA1 CYSRT1 ECT2 FANCL GGNBP1 GGNBP2 GOLGA2 GRB2 HOMER3 HSF2BP KRT40 KRTAP2-3 KRTAP2-4 KRTAP5-9 MTUS2 NCK2 OAZ3 OSTF1 RACK1 SH3KBP1 SH3RF1 WWP2 ZMYND19	48 interacting genes: ACTMAP ACVR1 ANTKMT BMPR1B CADPS CERCAM CHCHD3 CTBP1 CTDSP1 CYB5R2 DDAH2 DOCK8 EIF4ENIF1 FAAP100 FANCB FANCD2 FANCF FANCI GATA1 GGN GRN HDHD3 HES1 HOXD4 ID2 IHO1 IKZF3 KIFC3 KRTAP11-1 KRTAP13-2 KRTAP19-6 LZTS2 METTL15 MORN3 PCNA RBM45 RIMBP3 RNF11 SCNM1 SNF8 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W UFSP1 YPEL3 ZNF581
Entrez ID		199720	55120
HPRD ID		17036	06997
Ensembl ID		ENSG00000179168	ENSG00000115392
Uniprot IDs		Q86UU5	A0A8Q3SIK5 A0A8Q3SIR9 C9J512 H7C1M0 Q9NW38
PDB IDs			3ZQS 4CCG 7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Regulation Of Cytoskeleton Organization Cytoplasm Cellular Response To Ionizing Radiation Protein Autoubiquitination Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Intermediate Filament Signaling Adaptor Activity Positive Regulation Of Intracellular Protein Transport Keratin Filament Regulation Of Protein Transport Positive Regulation Of Protein Transport Cytoskeletal Anchor Activity Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Actin Filament Organization Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Metabolic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Binding Gamete Generation Response To Ionizing Radiation Positive Regulation Of Intracellular Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport Regulation Of Endoplasmic Reticulum Unfolded Protein Response Vesicle Membrane Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Protein Import Into Nucleus Guanyl-nucleotide Exchange Factor Adaptor Activity	Interstrand Cross-link Repair Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Fanconi Anaemia Nuclear Complex DNA Repair DNA Metabolic Process DNA Polymerase Binding Negative Regulation Of Neuron Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Protein Binding Cell Fate Commitment Ventricular Septum Morphogenesis BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition DNA Damage Response Nucleus SMAD Binding Activin Binding Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Chromatin DNA Repair Complex
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