ECT2 and PARD6A

Number of citations of the paper that reports this interaction (PubMedID 15254234)
43

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro)

		ECT2	PARD6A
Description		epithelial cell transforming 2	par-6 family cell polarity regulator alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Anchoring Junction Mitotic Spindle Centralspindlin Complex	Ruffle Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Centriolar Satellite Cell Projection Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity	Protein Binding GTP-dependent Protein Binding Small GTPase Binding
	Biological Process	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly	Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Viral Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Centrosome
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle RHOV GTPase cycle
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)	Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN HACL2 KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2	27 interacting genes: APP CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ SNCA TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ
Entrez ID		1894	50855
HPRD ID		11860	06316
Ensembl ID		ENSG00000114346	ENSG00000102981
Uniprot IDs		Q9H8V3	Q9NPB6
PDB IDs		3L46 4N40 6L30	1WMH
Enriched GO Terms of Interacting Partners?		Cytosol Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Intracellular Signal Transduction Regulation Of Cellular Component Organization Bicellular Tight Junction PAR Polarity Complex Positive Regulation Of Cellular Component Organization Establishment Of Cell Polarity Cell-cell Junction Organization Diacylglycerol-dependent Serine/threonine Kinase Activity Cell Junction Organization Cell-cell Junction Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity Apical Part Of Cell Signal Transduction Positive Regulation Of Protein Localization Cell Cortex Tight Junction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synaptic Plasticity Regulation Of Protein Localization Protein Kinase Activity Regulation Of Developmental Process Protein Phosphorylation Positive Regulation Of Cellular Component Biogenesis Protein Serine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Programmed Cell Death Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Phosphorylation GBD Domain Binding Regulation Of Cell Communication Regulation Of Signaling Anchoring Junction Kinase Activity Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytoplasm Supramolecular Fiber Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Postsynaptic Cytosol
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